Abstract：Objective：To observe the clinical effect of penetrating acupuncture with elongated needle plus moxibustion combined with western medicine for peripheral facial paralysis with phlegm- stasis obstructing the collaterals syndrome. Methods： A total of 86 cases of patients with peripheral facial paralysis with phlegm-stasis obstructing the collaterals syndrome were divided into the control group and the observation group according to the random number table method，with 43 cases in each group. The control group was treated with Prednisone Tablets，Mecobalamin Tablets，and Vitamin B 1 Tablets，and the observation group was additionally treated with penetrating acupuncture with elongated needle plus moxibustion based on the treatment of the control group. Both groups were treated for 2 weeks. Clinical effects were compared between the two groups. The scores of Facial Disability Index (FDI) and Toronto Facial Grading System (TFGS)，and immunoglobulin (Ig) levels were compared between the two groups before and after treatment . The incidence of adverse reactions were recorded. Results：After treatment， the total clinical effective rate was 95.35% in the observation group，higher than that of 79.07% in the control group (P＜0.05). The scores of social function in FDI in the two groups were decreased (P＜0.05)， and the scores of physical function in FDI and TFGS were increased (P＜0.05)；the score of social function in FDI in the observation group was lower than that in the control group (P＜0.05)， and the scores of physical function in FDI and TFGS in the observation group were higher than those in the control group (P＜ 0.05). The levels of IgM，IgA，and IgG in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the 3 levels in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 16.28% in the observation group and 13.95% in the control group，there was no significant difference being found in the comparison between the two groups (P＞0.05). Conclusion：On the basis of western medicine，penetrating acupuncture with elongated needle plus moxibustion for peripheral facial paralysis with phlegm- stasis obstructing the collaterals syndrome can enhance curative effect and regulate body immune function，with good safety.