Abstract：The authors discuss and analyze the application of commonly-used Chinese herbs in Lingnan area and their herbal pairs in digestive system disease. The natures and flavors， meridian entries and effects of totally 12 commonly-used Chinese herbs in Lingnan area are summarized and introduced in this paper，including Fici Simplicissimae Radix and Dendrobii Caulis for reinforcing the healthy qi，Flos Jasmini for moving qi and relieving pain，Ilicis Cortex Rotundae，Jasminum Elongatum，Herba Hyperici Japonici and Polygonum Chinense for clearing heat and dispelling dampness， Striga Asiatica and Microcos Paniculata for promoting digestion and guiding out food stagnation，Callicarpa Pedunculata and Melastoma dodecandrum Lour for cooling the blood and stanching bleeding，and Hedyotis Diffusa for resolving toxins and suppressing cancer so as to further analyze the commonly-used Chinese herbal pairs to treat digestive system diseases and their effects.