Abstract： Objective： To observe the effect of moxibustion at governor vessel on sex hormones and immune function in patients after vaginal myomectomy. Methods： A total of 120 cases of patients with vaginal myomectomy of yang deficiency and congealing cold type were selected and divided into the observation group and the control group according to the random number table method，with 60 cases in each group. After surgery，the control group was given the oral administration of Mifepristone Tablets，and the observation group was treated with Mifepristone Tablets combined with moxibustion at governor vessel. Both groups were treated for 6 months. The levels of sex hormones [follicle- stimulating hormone (FSH)， estradiol (E2)， luteinizing hormone (LH)， and progesterone (P) in serum] and cellular immune function indexes (CD3 +，CD4 +，CD8 + ) in the two groups were detected before and after treatment. The clinical effects in the two groups were compared. The recurrence in 6 months and 12 months after surgery was counted. Results：After treatment，the total effective rate in the observation group was higher than that in the control group (P＜0.05). After treatment，the levels of sex hormones including FSH，E2，LH， and P in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of above four indexes in the observation group were lower than those in the control group (P＜ 0.05). The levels of CD3 + and CD4 + in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of CD8+ were decreased when compared with those before treatment (P＜0.05)；the levels of CD3+ and CD4+ in the observation group were higher than those in the control group (P＜0.05)， and the level of CD8 + was lower than that in the control group (P＜0.05). The 12- month recurrence rate and total recurrence rate in the observation group were lower than those in the control group (P＜0.05). Conclusion：Moxibustion at governor vessel for patients with hysteromyoma of yang deficiency and congealing cold type after vaginal myomectomy can effectively regulate their levels of progesterone and estrogen，improve immune function，and reduce recurrence of hysteromyoma，with a significant clinical effect.