Abstract： Objective： To observe the clinical effect of moxibustion with seed- sized moxa cone and Shuxuetong Injection combined with routine therapy for hand dysfunction after cerebral infarction. Methods：A total of 180 cases of patients with hand dysfunction after cerebral infarction with qi deficiency and blood stasis syndrome were divided into the observation group and the control group according to the random number table method， with 90 cases in each group. The control group was treated with routine therapy and Shuxuetong Injection， and the observation group was additionally treated with moxibustion with seed-sized moxa cone based on the treatment of the control group. Both groups were treated for 2 courses，with 2 weeks being 1 course. Before and after treatment，motor function of the affected hand was evaluated by Fugl-Meyer Assessment Scale (FMA)，comprehensive function of the affected hand was evaluated by hemiplegic hand function rating scale，degree of neurological deficit of the affected hand was evaluated by Neurological Disability Score (NDS)， and integrated electromyography (iEMG) of muscles in wrist the affected hand was detected by EMG equipment； the levels of neuron- specific enolase (NSE)， S100B protein，vascular endothelial growth factor (VEGF)，interleukin- 18 (IL- 18)，interleukin- 6 (IL- 6)， platelet molecular marker 1 (PAC- 1)，and D- dimer (D- D) in serum were detected. The clinical effects in the two groups were compared. Results：After treatment，the total clinical effective rate was 98.89% in the observation group and 85.56% in the control group， the difference being significant (P＜0.05). The scores of FMA and hemiplegic hand function rating scale in the two groups were increased when compared with those before treatment， differences being significant (P＜0.05)， and the scores of FMA and hemiplegic hand function rating scale in the observation group were higher than those in the control group (P＜0.05). The NDS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the NDS score in the observation group was lower than that in the control group (P＜0.05). The iEMG values in muscles of wrist dorsiflexion and wrist palmar flexion in the two groups were increased when compared with those before treatment (P＜0.05)， and the iEMG values in muscles of wrist dorsiflexion and wrist palmar flexion in the observation group were higher than those in the control group (P＜0.05). The levels of NSE，S100B protein，IL-18，IL-6，PAC-1，and D-D in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and VEGF levels in serum were increased when compared with those before treatment (P＜0.05)； the levels of NSE， S100B protein， IL- 18，IL- 6，PAC- 1，and D- D in serum in the observation group were lower than those in the control group (P＜0.05)， and the VEGF level in serum was higher than that in the control group (P＜0.05). Conclusion：On the basis of routine treatment for cerebral infarction and routine rehabilitation therapy，the additional treatment of moxibustion with seed-sized moxa cone combined with Shuxuetong Injection has a definite effect in treating hand dysfunction after cerebral infarction of qi deficiency and blood stasis type， which can effectively reduce the degree of neurological deficit of the affected hand and local inflammation of cerebral infarction，improve blood circulation of the brain and the strength of muscles of wrist dorsiflexion and wrist palmar flexion of the affected hand，and enhance the comprehensive hand function.