Abstract：Objective：To observe the curative effect of Compound Xueshuantong Capsules combined with Compound Betamethasone for oral lichen planus and its effect on the levels of serum inflammatory factors. Methods：A total of 88 cases of oral lichen planus patients were divided into the control group and the treatment group according to the random number table method， with 44 cases in each group. The control group was treated with Compound Betamethasone and the treatment group was additionally treated with Compound Xueshuantong Capsules based on the treatment of the control group. Both groups were treated for one month. The scores of symptoms and signs， Visual Analogue Scale (VAS) scores ， hemorheology indexes ， and levels of inflammatory factors including interleukin- 2 (IL- 2) ， interleukin- 10 (IL- 10)，and tumor necrosis factor- α (TNF- α) were compared before and after treatment between the two groups；clinical effects and adverse reactions were analyzed. Results：The total effective rate was 97.73% in the treatment group and 84.09% in the control group，the difference being significant (P＜0.05). After treatment，the scores of symptoms，signs，and VAS in the two groups were decreased when compared with those before treatment， and the above scores in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of plasma viscosity， fibrinogen， platelet aggregation rates，and hematocrit in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above indexes in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of IL- 2， IL- 10， and TNF- α in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above indexes in the treatment group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 4.55% in the treatment group and 11.36% in the control group， there being no significant difference between the two groups (P＞0.05). Conclusion：Compound Xueshuantong Capsules combined with Compound Betamethasone has a definite curative effect in the treatment of oral lichen planus，which can effectively inhibit the inflammatory responses of the body， improve the clinical signs and symptoms and high blood agglutination state of patients and significantly reduce pain， with relatively fewer adverse reactions.