Abstract：Objective：To observe the effect of therapy of Xin Zishui Pinggan Decoction and acupuncture combined with Levodopa Benserazide Tablets on Parkinson's disease of liver and kidney insufficiency type. Methods： A total of 112 patients with Parkinson's disease of liver and kidney insufficiency type were randomly divided into the Chinese medicine group and the western medicine group. The western medicine group was treated with Levodopa Benserazide Tablets，and the Chinese medicine group was additionally given Xin Zishui Pinggan Decoction combined with acupuncture based on the treatment of the control group. The two groups were treated for 12 weeks. The clinical effects were compared between the two groups； before and after treatment，the traditional Chinese medicine (TCM) syndrome scores and scores of Unified- Parkinson's Disease Rating Scale (UPDRS) in the two groups were evaluated；the P300 incubation period and P300 wave amplitude were measured； the neurotransmitters were detected， including dopamine (DA)，5- hydroxytryptamin (5- HT) and neurotrophin- 3 (NT- 3)；the incidence of adverse reactions during treatment was counted. Results：After treatment，the total clinical effective rate in the Chinese medicine group was higher than that in the western medicine group (P＜0.05). The TCM syndrome scores and UPDRS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above two scores in the Chinese medicine group were lower than those in the western medicine group (P＜ 0.05). The P300 incubation period in both groups were shortened when compared with those before treatment (P＜0.05)，and the P300 incubation period in Chinese medicine group was shorter than that in the western group (P＜0.05). The P300 wave amplitude in the two groups were increased when compared with those before treatment (P＜0.05)，and the P300 wave amplitude in the Chinese medicine group was higher than that in the western medicine group (P＜0.05). The levels of NT-3，5-HT and DA in both groups were increased when compared with those before treatment (P＜0.05)， and the above three levels in the Chinese medicine group were higher than those in the western medicine group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Xin Zishui Pinggan Decoction and acupuncture combined with Levodopa Benserazide Tablets has a significant effect on Parkinson's disease of liver and kidney insufficiency type，which can further mitigate the clinical symptoms，regulate the levels of neurotransmitters and improve the cognitive function with good safety.