Abstract： Objective： To observe the clinical effect of Wenjing Tongluo Powder combined with occupational therapy for shoulder pain after stroke. Methods：The data of 62 cases of patients with shoulder pain after stroke were given retrospective analysis and divided into the control group and the observation group according to different treatment methods， with 31 cases in each group. The control group was intervened with occupational therapy， and the observation group was additionally treated with Wenjing Tongluo Powder based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores，Visual Analogue Scale (VAS) scores，Fugl-Meyer Assessment (FMA) scores，Modified Barthel Index (MBI) and shoulder joint mobility before and after treatment， and the clinical effects and incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 93.54% in the observation group and 80.64% in the control group，the difference being significant (P＜ 0.05). After treatment，the TCM syndrome scores including shoulder pain，hemiplegia，mental confusion， short breath and fatigue， limb paralysis， and pale and dingy tongue in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). After treatment，VAS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，the scores of FMA and MBI were increased when compared with those before treatment (P＜0.05)，and the improvement of the above three scores in the observation group were better than that in the control group (P＜0.05). After treatment，the shoulder joint mobility including anteflexion， posterior extension， abduction， inward rotation， and outward rotation in the two groups was increased when compared with that before treatment (P＜0.05)， and the above shoulder joint mobility in the observation group was larger than that in the control group (P＜ 0.05). The incidence of adverse reactions was 6.45% in the observation group and 19.35% in the control group， the difference being significant (P＜0.05). Conclusion： Wenjing Tongluo Powder combined with occupational therapy for shoulder pain after stroke can improve the curative effect and help to relieve pain， improve TCM syndromes，upper limb motor function，shoulder joint function，and abilities of daily living， and reduce adverse reactions.