非酒精性脂肪性肝病常见中医分型与超声参数关系研究
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R575

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湖州市科学技术局公益性应用研究医卫一般项目(2021GY31)


Study on Relationship Between Traditional Chinese Medicine Syndrome Types and Ultrasonic Parameters of Nonalcoholic Fatty Liver Disease
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    摘要:

    目的:探讨非酒精性脂肪性肝病(NAFLD) 常见中医分型与超声参数的关系。方法:回顾性选取 2019 年3 月—2022 年3 月湖州市南浔区中医院收治的120 例NAFLD 患者为研究对象,根据中医分型将患者 分为肝郁脾虚证组(46 例)、湿浊内停证组(25 例)、湿热蕴结证组(21 例)、痰瘀互结证组(17 例)、脾肾两 虚证组(11 例) 5 组。比较各组体质量指数(BMI)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽 酶(GGT)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL) 水平;比较各组超声脂肪肝分级、 声衰减成像参数(ATI) 和受控衰减参数(CAP)。结果:痰瘀互结证组、脾肾两虚证组BMI、ALT、AST、 GGT、TG 水平均明显高于肝郁脾虚证组、湿浊内停证组、湿热蕴结证组(P<0.05)。各组TC、LDL 水平及肝 郁脾虚证组、湿浊内停证组和湿热蕴结证组BMI、ALT、AST、GGT、TG 水平比较,差异均无统计学意 义(P>0.05)。湿浊内停证组、湿热蕴结证组、痰瘀互结证组、脾肾两虚证组CAP 值、ATI 值均大于肝郁脾虚 证组(P<0.05);痰瘀互结证组、脾肾两虚证组CAP 值、ATI 值均大于湿浊内停证组、湿热蕴结证组(P< 0.05)。肝郁脾虚证组轻度脂肪肝占比高于湿浊内停证组、湿热蕴结证组、痰瘀互结证组和脾肾两虚证组(P< 0.05),湿浊内停证组、湿热蕴结证组中度脂肪肝占比高于肝郁脾虚证组、痰瘀互结证组、脾肾两虚证组(P< 0.05),痰瘀互结证组、脾肾两虚证组重度脂肪肝占比高于肝郁脾虚证组、湿浊内停证组、湿热蕴结证组(P< 0.05)。相关性分析显示,CAP 值、ATI 值与脂肪肝超声分级均呈正相关(P<0.05)。结论:NAFLD 患者中医 分型与脂肪肝超声分级、CAP 和ATI 等超声参数存在相关性,痰瘀互结证、脾肾两虚证超声脂肪肝分级以重 度为主,CAP 值、ATI 值偏高。

    Abstract:

    Abstract: Objective: To investigate the relationship between traditional Chinese medicine (TCM) syndrome types and ultrasonic parameters of nonalcoholic fatty liver disease (NAFLD). Methods:A total of 120 cases with NAFLD admitted to Nanxun Branch of Zhejiang Hospital of Traditional Chinese Medicine from March 2019 to March 2022 were retrospectively selected as the research objects. According to the TCM syndrome types, patients were divided into five groups: syndrome of liver constraint and spleen deficiency (46 cases),syndrome of internal retention of damp- turbidity (25 cases),syndrome of damp- heat accumulation (21 cases), syndrome of phlegm blended with stasis (17 cases), and syndrome of spleen- kidney deficiency (11 cases). The levels of body mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), triglyceride (TG), cholesterol (TC) and low density lipoprotein (LDL) in all groups were compared. The ultrasonic fatty liver grading, acoustic attenuation imaging parameters (ATI) and controlled attenuation parameters (CAP) were compared between the groups. Results:The levels of BMI,ALT,AST,GGT and TG in the group of syndrome of phlegm blended with stasis and the group of syndrome of spleen- kidney deficiency were significantly higher than those in the group of syndrome of liver constraint and spleen deficiency,the group of syndrome of internal retention of damp- turbidity and the group of syndrome of damp- heat accumulation (P<0.05). There was no significant difference in the levels of TC and LDL in the all groups and in the levels of BMI, ALT,AST,GGT and TG in the group of syndrome of liver constraint and spleen deficiency,the group of syndrome of internal retention of damp- turbidity and the group of syndrome of damp- heat accumulation (P>0.05). The levels of CAP and ATI in the group of internal retention of damp- turbidity, the group of syndrome of damp- heat accumulation, the group of phlegm blended with stasis and the group of syndrome of spleen-kidney deficiency were higher than that in the group of syndrome of liver constraint and spleen deficiency (P<0.05);the levels of CAP and ATI in the group of phlegm blended with stasis and the group of syndrome of spleen-kidney deficiency were higher than those in the group of syndrome of internal retention of damp- turbidity and the group of syndrome of damp- heat accumulation (P<0.05). The proportion of mild fatty liver in the group of syndrome of liver constraint and spleen deficiency was larger than that in the group of syndrome of internal retention of damp-turbidity,the group of syndrome of dampheat accumulation, the group of syndrome of phlegm blended with stasis and the group of syndrome of spleen- kidney deficiency (P<0.05); the proportion of moderate fatty liver in the group of syndrome of internal retention of damp-turbidity and the group of syndrome of damp-heat accumulation was larger than that in the group of syndrome of liver constraint and spleen deficiency,the group of syndrome of phlegm blended with stasis and the group of syndrome of spleen- kidney deficiency (P<0.05); the proportion of severe fatty liver in the group of syndrome of phlegm blended with stasis and the group of syndrome of spleen- kidney deficiency was larger than that in the group of syndrome of liver constraint and spleen deficiency, the group of syndrome of internal retention of damp- turbidity and the group of syndrome of damp- heat accumulation (P<0.05). Correlation analysis showed that CAP and ATI levels were positively correlated with ultrasonic grading of fatty liver (P<0.05). Conclusion:The TCM syndrome types of NAFLD patients is correlated with ultrasonic grading,CAP,ATI and other parameters of fatty liver. The ultrasonic fatty liver classification in patients with syndrome of phlegm blended with stasis or with syndrome of spleen-kidney deficiency is mainly severe,with high CAP and ATI levels.

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孙贤,黄赟琪,朱红,褚娟红.非酒精性脂肪性肝病常见中医分型与超声参数关系研究[J].新中医,2023,55(11):99-104

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  • 在线发布日期: 2023-06-16
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