Abstract： Objective： To observe the effect of Xuesaitong Injection combined with Butylphthalide Capsules on serum inflammatory factors，hemodynamics，and neurological function in patients with acute cerebral infarction. Methods：A total of 100 cases of patients with acute cerebral infarction were selected as research objects and divided into two groups according to the random number table method，with 50 cases in each group. The control group was treated with Butylphthalide Capsules， and the study group was additionally treated with Xuesaitong Injection based on the treatment of the control group. Before and after treatment，the levels of matrix metalloproteinase-9 (MMP-9)，S-100B protein，neuron-specific enolase (NSE)，soluble interleukin-2 receptor (sIL-2R)，interleukin-18 (IL-18)，vascular endothelial growth factor (VEGF)，the pulsatility index (PI)，mean blood velocity (Vm)，and resistance index (RI) of middle cerebral artery，and the scores of National Institutes of Health Stroke Scale (NIHSS) and Stroke-specific Quality of Life (SS- QOL) were compared between the two groups. The clinical effects in the two groups were compared. Results：Before treatment，there was no significant difference being found in the comparison of the levels of sIL-2R，IL-18，VEGF，S-100B protein，NSE，and MMP-9 between the two groups (P＞ 0.05). After treatment， VEGF levels in the two groups were increased (P＜0.05)， and VEGF level in the study group was higher than that in the control group； the levels of sIL- 2R， IL- 18， S- 100B protein， NSE，and MMP-9 in the study group were decreased (P＜0.05)，and the above levels in the study group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of PI，Vm and RI in brain between the two groups (P＞0.05). After treatment，the Vm levels in the two groups were increased (P＜0.05)，and the Vm level in the study group was higher than that in the control group (P＜0.05)，the levels of PI and RI in the two groups were decreased (P＜0.05)， and the levels in the study group were lower than those in the control group (P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of the scores of NIHSS and SS-QOL between the two groups (P＞0.05). After treatment，the SS-QOL scores in the two groups were increased (P＜0.05)，and the SS- QOL score in the study group was higher than that in the control group (P＜0.05)；the NIHSS scores in the two groups were decreased (P＜0.05)，and the NIHSS score in the study group was lower than that in the control group (P＜0.05). The total effective rate was 96.00% in the study group， higher than that of 80.00% in the control group (P＜0.05). Conclusion： Xuesaitong Injection combined with Butylphthalide Capsules for patients with acute cerebral infarction can inhibit inflammation， improve hemodynamics and neurological function， and enhance clinical effect and quality of life.