Abstract： Objective： To observe the clinical effect of Runzao Zhiyang Capsules combined with Ebastine Tablets and Hydrocortisone Butyrate Cream for chronic eczema. Methods：A total of 150 cases of patients with chronic eczema were selected and randomly divided into the observation group and the control group according to the odd- even number method， with 75 cases in each group. The control group was treated with Ebastine Tablets and Hydrocortisone Butyrate Cream， and the observation group was additionally treated with Runzao Zhiyang Capsules based on the treatment of the control group. Both groups were treated for 2 courses，with 1 month being a course of treatment. The clinical effects，the scores of skin lesion degree and itching degree，the laboratory indexes [eosinophils (EOS)，immunoglobulin E (IgE)， interleukin- 4 (IL- 4)， eosinophilic cationic protein (ECP)] and skin physiological function were compared between the two groups. Results：The total effective rate was 94.67% in the observation group，higher than that of 84.00% in the control group，the difference being significant (P＜0.05). After treatment，the scores of skin lesion degree and itching degree in the two groups were decreased when compared with those before treatment (P＜0.05)， and the scores of skin lesion degree and itching degree in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of EOS，IgE，IL-4，and ECP in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above indexes in the observation group were lower than those in the control group (P＜ 0.05). After treatment，the levels of sebum content (SC) and water content of stratum corneum (WCSC) in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of transepidermal water loss (TEWL) were decreased when compared with those before treatment (P＜0.05)； the levels of SC and WCSC in the observation group were higher than those in the control group (P＜0.05)， and the level of TEWL was lower than that in the control group (P＜0.05). Conclusion： Runzao Zhiyang Capsules combined with Ebastine Tablets and Hydrocortisone Butyrate Cream has a definite curative effect in the treatment of patients with chronic eczema，which can effectively relieve the degree of skin lesions and itching， relieve inflammatory responses of the body， and improve immune status and physiological function of skin.