Abstract： Objective： To observe the clinical effect of the therapy of modified Hongteng Baijiang Decoction combined with western medicine on chronic pelvic inflammatory disease (CPID) of damp- heat stasis obstruction type. Methods：A total of 136 CPID patients of damp-heat stasis obstruction type were randomly divided into the control group and the observation group，with 68 cases in each group. The two groups were given Levofloxacin Tablets and Metronidazole Tablets for treatment， and the observation group was additionally treated with modified Hongteng Baijiang Decoction. With 2 weeks as a course of treatment， the two groups were treated for 2 courses. Before and after treatment， the scores of Visual Analogue Scale (VAS) for pain in lower abdomen and lumbosacral portion， traditional Chinese medicine (TCM) syndrome scores and signs scores， and quality of life scores were evaluated； the inflammatory factors，including C-reactive protein (CRP)，interleukin-6 (IL-6)，interleukin-8 (IL-8) and tumor necrosis factor- α (TNF- α)， and indexes of hemorheology， including whole blood high- shear viscosity， whole blood low- shear viscosity， plasma viscosity and erythrocyte sedimentation rates were detected； the clinical effects were evaluated after treatment， and adverse reactions were recorded during treatment. Results：After 2 courses of treatment，the total effective rate was 92.65% in the observation group and 70.59% in the control group， the difference being significant (P＜0.05). The TCM syndrome scores and signs scores，and VAS scores for pain in the lower abdomen and lumbosacral portion in both groups were decreased when compared with those before treatment (P＜0.05)；the above four scores in the observation group were lower than those in the control group (P＜0.05). The scores of psychology， physiology， environment and society in the two groups were increased when compared with those before treatment (P＜0.05)，and the above four scores in the observation group were higher than those in the control group (P＜0.05). The levels of serum CRP， IL- 6， IL- 8， and TNF- α， and whole blood high- shear viscosity， whole blood low- shear viscosity， plasma viscosity and erythrocyte sedimentation rates in both groups were decreased when compared with those before treatment (P＜0.05)， and the above eight indexes of hemorheology in the observation group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The therapy of modified Hongteng Baijiang Decoction combined with western medicine for CPID of damp-heat stasis obstruction type can enhance the clinical effect and antiinflammatory effect， effectively mitigate relevant symptoms of pain， and improve the quality of life of patients with good safety.