Objective： To observe the curative effect of therapy of Danshen Chuanxiongqin Injection combined with thrombosis on patients with acute cerebral infarction (ACI) and its effect on hemorheology. Methods：Using the estimation method of superiority sample size，a total of 80 ACI patients were selected and divided into the control group and the treatment group according to the random number table method， with 40 cases in each group. The control group was given thrombosis for treatment， and the treatment group was additionally treated with Danshen Chuanxiongqin Injection based on the treatment of the control group. After four weeks of treatment，the clinical effects in the two groups were determined；the changes of scores of Chinese Stroke Scale (CSS)，indexes of hemorheology，including plasma viscosity，levels of hematocrit (Hct) and fibrinogen (Fib) and platelet aggregation rates，thromboxane B2 (TXB2)，and levels of calcitonin generated peptide (CGRP)， homocysteine (Hcy) and atrial natriuretic polypeptide (ANP) in both groups were recorded and compared；the incidence of adverse reactions (AR) were compared between the two groups. Results：The total clinical effective rate was 92.50% in the treatment group and 72.50% in the control group，the difference being significant (P＜0.05). After 1 week，2 and 4 weeks of treatment，the CSS scores in both groups were obviously lower than those before treatment，differences being significant (P＜0.05)，and the CSS score in the treatment group at each time point was lower than those in the control group，differences being significant (P＜0.05). After 4 weeks of treatment，the CGRP levels in plasma in the two groups were significantly higher than those before treatment， differences being significant(P＜ 0.05)，and the plasma viscosity，levels of Fib and Hct，platelet aggregation rates and levels of TXB2，Hcy and ANP in plasma were obviously lower than those before treatment， differences being significant(P＜ 0.05)；the CGRP level in plasma in the treatment group was higher than that in the control group，and the plasma viscosity， levels of Fib and Hct， platelet aggregation rate and levels of TXB2， Hcy and ANP in plasma were lower than those in the control group，differences being significant(P＜0.05)；there was no significant difference being found in the comparison of total incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Danshen Chuanxiongqin Injection combined with thrombosis for ACI can significantly reduce the injuries of nerve function， and effectively improve the indexes of hemorheology and levels of TXB2，CGRP，Hcy and ANP.