Abstract： Objective： To observe the clinical effect of modified Yiqi Yangyin Tongluo Prescription combined with rehabilitation training for Parkinson disease (PD) of deficiency of both qi and yin type. Methods ： A total of 120 cases of PD patients were enrolled into the study and divided into the control group and the treatment group according to odd-even number method，with 60 cases in each group. The control group was treated with Dobutazine Tablets，and the treatment group was treated with Yiqi Yangyin Tongluo Prescription combined with rehabilitation training. After 3- month treatment，clinical effects，the dysfunction scores of tremor syndrome， score of the Scales for Outcomes in Parkinson's Disease- Autonomic (SCOPA- AUT) and Motor Dysfunction Rating Scale for Parkinson's Disease (MDRSPD)， and levels of serum neurotrophic factors [brain-derived neurotrophic factor (BDNF)，insulin-like growth factor 1 (IGF-1)，and human neurotrophic factor 3 (NT-3)] were evaluated in the two groups. Results：The total effective rate was 93.33% in the treatment group， higher than that of 80.00% in the control group， the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of dysfunction scores of tremor syndrome between the two groups (P＞0.05). After treatment，dysfunction scores of tremor syndrome in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores in the treatment group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of SCOPA- AUT and MDRSPD between the two groups (P＞0.05). After treatment，the scores of SCOPA- AUT and MDRSPD in the two groups were significantly decreased when compared with those before treatment (P＜0.05)，and the two scores in the treatment group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of BDNF， IGF- 1， and NT- 3 in serum between the two groups (P＞0.05). After treatment， the levels of BDNF，IGF- 1，and NT- 3 in the two groups were increased when compared with those before treatment (P＜0.05)，and the 3 indexes in the treatment group were significantly higher than those in the control group (P＜0.05). Conclusion：Yiqi Yangyin Tongluo Prescription combined with rehabilitation training has a definite curative effect in treating PD and can relieve clinical symptoms， improve the autonomic nervous symptoms and motor function of patients， and regulate the levels of neurotrophic factors， thus delaying the progress of the disease.