Abstract：Objective：To observe the clinical effect of the therapy of Suxiao Jiuxin Pills combined with Clopidogrel Tablets on acute coronary syndrome (ACS). Methods：A total of 65 ACS patients were divided into the observation group (33 cases) and the control group (32 cases) according to random number table method. The control group was treated with Clopidogrel Tablets， and the observation group was additionally treated with Suxiao Jiuxin Pills based on the treatment of the control group. The clinical effects， angina frequency，ST segment displacement，the levels of hypersensitive C- reactive protein (hs- CRP)， the levels of brain natriuretic peptide (BNP) and the incidence of adverse cardiovascular events were compared between the two groups. Results：The total clinical effective rate was 93.94% in the observation group and 71.88% in the control group，the difference between the two groups being significant (P＜0.05). Before treatment， there was no significant difference in angina frequency and ST segment displacement amplitude between the two groups (P＞0.05). After treatment， the angina frequency and ST segment displacement in the two groups were decreased when compared with those before treatment (P＜0.05)， and the angina frequency and ST segment displacement amplitude in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference in the levels of serum hs- CRP and BNP between the two groups (P＞0.05). After treatment， the levels of hs- CRP and BNP in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above two levels in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse cardiovascular events was 3.03% in the observation group and 21.88% in the control group，the difference being significant (P＜0.05). Conclusion：The therapy of Suxiao Jiuxin Pills combined with Clopidogrel Tablets has a significant effect on the treatment of ACS， which can reduce the inflammatory responses of the body， reduce the angina frequency and the ST segment displacement amplitude，improve the heart function and reduce the incidence of adverse cardiovascular events.