Abstract：Objective：To observe the clinical effect of Angong Niuhuang Pills combined with western medicine for severe cerebral hemorrhage with the syndrome of phlegm-heat internally blocking the seven orifices and its effects on neurologic function and inflammatory responses of patients. Methods：A total of 96 cases of patients with severe cerebral hemorrhage with the syndrome of phlegm-heat internally blocking the seven orifices were selected and divided into the control group and the treatment group according to the random number table method ， with 48 cases in each group. The control group was treated with western medicine ， while the treatment group was treated with Angong Niuhuang Pills on the basis of the control group. Both groups were treated for 2 weeks. The scores of National Institutes of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) and the levels of serum inflammatory indexs before and after treatment，as well as the clinical effects were compared between the two groups. Results：After treatment，the total clinical effective rate was 93.75% in the treatment group，higher than that of 79.17% in the control group (P＜0.05). NIHSS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and GCS scores were increased when compared with those before treatment (P＜0.05)； NIHSS score in the treatment group was lower than that in the control group (P＜0.05)， and GCS score was higher than that in the control group (P＜0.05). The intracranial pressure in the two groups were decreased when compared with those before treatment (P＜0.05)， and the intracranial hematoma volume were decreased when compared with those before treatment (P＜0.05)；the intracranial pressure in the treatment group was lower than that in the control group (P＜0.05)，and intracranial hematoma volume was smaller than that in the control group (P＜0.05). The levels of hypersensitive C- reactive protein (hs- CRP) and tumor necrosis factor- α (TNF- α) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above 2 levels in the treatment group were lower than those in the control group (P＜0.05). Conclusion：Angong Niuhuang Pills combined with western medicine has a significant curative effect in the treatment of severe cerebral hemorrhage with the syndrome of phlegm- heat internally blocking the seven orifices，which is helpful to reduce the degree of neurological impairment，improve coma and inhibit inflammatory responses.