Abstract ： Objective ： To observe the clinical effect of modified Xiuhe Prescription combined with TC (taxol+carboplatin) chemotherapy for ovarian cancer in middle and late stage. Methods ： A total of 74 patients with ovarian cancer in middle and late stage with deficiency of qi and blood syndrome were divided into the control group and the observation group according to the random number table method， with 37 cases in each group. The control group was given TC chemotherapy ，and the observation group was additionally treated with modified Xiuhe Prescription based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effects in the two groups were evaluated. Before and after treatment，traditional Chinese medicine syndrome scores，levels of tumor markers and immune function were compared between the two groups. The incidence of adverse reactions in the two groups was counted. Results： The total effective rate in the observation group was higher than that in the control group， the difference being significant (P＜0.05). After treatment， the scores of main and secondary symptoms and the total scores in the two groups were lower than those before treatment (P＜0.05)，and the scores of main and secondary symptoms and the total scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of alpha-fetoprotein (AFP)，carbohydrate antigen 125 (CA125)，and carbohydrate antigen 153 (CA153) in serum in the two groups were lower than those before treatment (P＜0.05)，and the levels of AFP，CA125 and CA153 in serum in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of CD3+，CD4+ and CD4+/CD8+ in the control group were lower than those before treatment (P＜0.05)，and the levels of CD3+， CD4 + and CD4 +/CD8 + in the observation group were higher than those in the control group (P＜0.05). The incidence of myelosuppression in the observation group was lower than that in the control group (P＜0.05). Conclusion：Modified Xiuhe Prescription combined with TC chemotherapy can reduce clinical symptoms in patients with ovarian cancer in middle and late stage，improve anti- cancer effect，inhibit levels of tumor markers in serum，avoid the decline of immune function of T cells，and reduce myelosuppression.