Abstract：Objective：To observe the clinical effect of Jideshu Pills combined with western medicine for ankylosing spondylitis and its effects on the levels of serum inflammatory factors and bone metabolism. Methods：A total of 109 cases of patients with ankylosing spondylitis were divided into the control group and the observation group according to the random number table method，with 54 and 55 cases in each group respectively. The control group was treated with routine western medicine， and the observation group was additionally treated with Jideshu Pills based on the treatment of the control group. Traditional Chinese medicine (TCM) syndrome scores， spinal function indexes， the Visual Analogue Scale (VAS) scores， and the levels of serum bone metabolism and inflammatory factors were compared before and after treatment between the two groups. Clinical effects and safety were evaluated in the two groups. Results： The total effective rate in the observation group was higher than that in the control group (P＜ 0.05). After treatment，TCM syndrome scores，Bath Ankylosing Spondylitis Functional Index (BASFI)，VAS scores，the occipital bone-to-wall distance，and finger-to-ground distance in the two groups were lower than those before treatment (P＜0.05)， the TCM syndrome scores， BASFI， VAS scores， the occipital bone-to-wall distance，and finger-to-ground distance in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of bone morphogenetic protein-2 (BMP-2)，bone gla protein (BGP)，and bone alkaline phosphatase (BALP) in the two groups were higher than those before treatment (P＜0.05)， and the above bone metabolism indexes in the observation group were higher than those in the control group (P＜0.05). The levels of macrophage migration inhibitory factor (MIF)， tumor necrosis factor- α (TNF- α)， and interleukin- 23 (IL- 23) in the two groups were lower than those before treatment (P＜0.05)，the levels of MIF，TNF-α，and IL-23 after treatment in the observation group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions (P＞0.05). Conclusion： Jideshu Pills combined with western medicine has significant effects in the treatment of patients with ankylosing spondylitis，which can effectively improve bone metabolism levels and spinal function and reduce the levels of serum inflammatory factors，with high safety.