Abstract： Objective： To observe the clinical effect of Guipi Decoction combined with Roxadustat for chronic kidney disease complicated with renal anemia. Methods：A total of 70 cases of patients with chronic kidney disease complicated with renal anemia were divided into the control group and the observation group according to the random number table method，with 35 cases in each group. The control group was treated with Roxadustat，and the observation group was treated with Guipi Decoction combined with Roxadustat. The levels of red blood cell count (RBC)，hemoglobin (Hb)，hematocrit (HCT)，and iron metabolism indexes including serum ferritin (SF) and transferrin saturation (TAST) were compared before and after treatment between the two groups. Results： Before treatment， there was no significant difference being found in the comparison of the levels of RBC， Hb， and HCT in blood between the two groups (P＞0.05). After treatment，the levels of RBC，Hb，and HCT in blood in the two groups were increased (P＜0.05)，and the above levels in the observation group were higher than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of SF and TAST in serum between the two groups (P＞0.05). After treatment，the levels of SF and TAST in serum in the two groups were increased (P＜0.05)，and the above levels in the observation group were higher than those in the control group (P＜0.05). Conclusion： Guipi Decoction combined with Roxadustat for chronic kidney disease complicated with renal anemia can effectively improve Hb levels and iron metabolism indexes of patients.