Abstract:Objective:To discuss the correlation between traditional Chinese medicine (TCM) syndrome types and helicobacter pylori (Hp) infection and immune function in patients with gastric cancer. Methods:A total of 82 cases of patients with gastric cancer were selected and divided into six types according to the criteria of syndrome differentiation:liver-stomach disharmony type,internal obstruction of stagnant toxin type,phlegm- damp coagulation type,spleen- stomach deficiency- cold type,qi- blood depletion type, and stomach heat damaging yin type. The Hp infection and immune function of patients of various TCM syndrome types were detected and compared. Results:Among 82 cases of patients with gastric cancer, there were 18 cases of liver- stomach disharmony type (21.95% ), 10 cases of internal obstruction of stagnant toxin type (12.20% ), 16 cases of phlegm- damp coagulation type (19.51% ), 16 cases of spleen-stomach deficiency-cold type (19.51%) , 13 cases of qi-blood depletion type (15.85%) , and 9 cases of stomach heat damaging yin type (10.98%),and there was no significant difference being found in the comparison of Hp positive rates among different TCM syndrome types (P>0.05). The comparison of the T lymphocyte levels of CD3 +,CD4 +,CD8 + between patients of liver- stomach disharmony type and those of qi- blood depletion type showed significance in the difference (P<0.05). The comparison of the levels of CD4 +/CD8 + among patients of liver- stomach disharmony type,phlegm- damp coagulation type, spleen-stomach deficiency-cold type,and qi-blood depletion type showed significance in the difference (P<0.05). The comparison of the levels of CD4+/CD8+ between patients of internal obstruction of stagnant toxin type and those of qi- blood depletion type showed significance in the difference (P<0.05). Conclusion: Hp infection has no significant effect on the TCM syndrome types of patients with gastric cancer,but the immune function of different TCM syndrome types is obviously different,suggesting that there is a close relationship between TCM syndrome types and immune function of gastric cancer patients.