Abstract：Objective：To discuss the correlation between traditional Chinese medicine (TCM) syndrome types and helicobacter pylori (Hp) infection and immune function in patients with gastric cancer. Methods：A total of 82 cases of patients with gastric cancer were selected and divided into six types according to the criteria of syndrome differentiation：liver-stomach disharmony type，internal obstruction of stagnant toxin type，phlegm- damp coagulation type，spleen- stomach deficiency- cold type，qi- blood depletion type， and stomach heat damaging yin type. The Hp infection and immune function of patients of various TCM syndrome types were detected and compared. Results：Among 82 cases of patients with gastric cancer， there were 18 cases of liver- stomach disharmony type (21.95% )， 10 cases of internal obstruction of stagnant toxin type (12.20% )， 16 cases of phlegm- damp coagulation type (19.51% )， 16 cases of spleen-stomach deficiency-cold type (19.51%) ， 13 cases of qi-blood depletion type (15.85%) ， and 9 cases of stomach heat damaging yin type (10.98%)，and there was no significant difference being found in the comparison of Hp positive rates among different TCM syndrome types (P＞0.05). The comparison of the T lymphocyte levels of CD3 +，CD4 +，CD8 + between patients of liver- stomach disharmony type and those of qi- blood depletion type showed significance in the difference (P＜0.05). The comparison of the levels of CD4 +/CD8 + among patients of liver- stomach disharmony type，phlegm- damp coagulation type， spleen-stomach deficiency-cold type，and qi-blood depletion type showed significance in the difference (P＜0.05). The comparison of the levels of CD4+/CD8+ between patients of internal obstruction of stagnant toxin type and those of qi- blood depletion type showed significance in the difference (P＜0.05). Conclusion： Hp infection has no significant effect on the TCM syndrome types of patients with gastric cancer，but the immune function of different TCM syndrome types is obviously different，suggesting that there is a close relationship between TCM syndrome types and immune function of gastric cancer patients.