Abstract： Objective： To observe the clinical effect of modified Yiqi Tongluo Decoction for cerebral infarction in convalescence and its effect on platelet activating factor (PAF)， homocysteine (HCY)， interleukin-18 (IL-18)，endothelin-1 (ET-1)，nitric oxide (NO)，and visfatin in serum. Methods：A total of 110 cases of patients with cerebral infarction in convalescence were divided into the treatment group and the routine group according to the random number table method，with 55 cases in each group. The routine group was treated with routine western medicine，and the treatment group was additionally treated with modified Yiqi Tongluo Decoction based on the treatment of the routine group. The traditional Chinese medicine (TCM) syndrome scores， vascular endothelial function， simplified Fugl- Meyer Assessment (FMA) scores， National Institutes of Health Stroke Scale (NIHSS) scores， and levels of PAF， HCY， IL- 18， and visfatin in serum before and after treatment， as well as the clinical effects were compared between the two groups. Results： The total clinical effective rate was 94.55% in the treatment group， higher than that of 72.73% in the routine group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of TCM syndrome scores including hemiplegia， mental confusion，sluggish speech，deviated mouth and tongue，white complexion，and short breath and fatigue between the two groups (P＞0.05). After treatment，the above TCM syndrome scores in the two groups were decreased (P＜0.05)， and the scores in the treatment group were lower than those in the routine group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of NO and ET-1 between the two groups (P＞0.05). After treatment，the NO levels in the two groups were increased (P＜0.05)， and ET- 1 levels were decreased (P＜0.05)； NO level in the treatment group was higher than that in the routine group (P＜0.05)，and ET-1 level was lower than that in the routine group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of FMA and NIHSS between the two groups (P＞0.05). After treatment，FMA scores in the two groups were increased (P＜0.05)，and NIHSS scores were decreased (P＜0.05)；the FMA score in the treatment group was higher than that in the routine group (P＜0.05)， and NIHSS score was lower than that in the routine group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of PAF，HCY，IL-18，and visfatin in serum between the two groups (P＞0.05). After treatment，the levels of PAF，HCY，IL-18，and visfatin in serum in the two groups were decreased (P＜0.05)，and the levels in the treatment group were lower than those in the routine group (P＞0.05). Conclusion：Modified Yiqi Tongluo Decoction combined with routine western medicine for convalescence of cerebral infarction can not only improve the clinical effective rates， TCM syndromes， vascular endothelial function， limb movement function and neurological function of patients，but also reduce the levels of PAF，HCY，IL-18， and visfatin in serum.