Abstract：Objective：To observe the clinical effect of the therapy of Zhibai Dihuang Pills combined with Dipherelin on idiopathic central precocious puberty (ICPP) in girls. Methods：A total of 106 cases of girls with ICPP were divided into the trial group and the control group according to the random number table method， with 53 cases in each group. The control group was treated with Dipherelin， and the trial group was additionally treated with Zhibai Dihuang Pills based on the treatment of the control group. Before and after treatment， the levels of sex hormones， growth and development indexes， secondary sex character indexes and traditional Chinese medicine (TCM) syndrome scores were compared between the two groups. The clinical effects and safety in the two groups were evaluated. Results： The total effective rate was 96.23% in the trial group，higher than that of 83.02% in the control group (P＜0.05). After treatment，the levels of serum sex hormones， including luteinizing hormone (LH)， estradiol (E2) and serum follicle stimulating hormone (FSH) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of LH，E2 and FSH in the trial group were lower than those in the control group (P＜0.05). After treatment， the TCM syndrome scores， bone age index and indexes of secondary sex character， including ovarian volume， uterine volume and diameter of mammillary nucleus in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome score，bone age index and indexes of secondary sex character in the trial group were lower than those in the control group (P＜0.05). After treatment， the Body Mass Indexes (BMI) in the two groups were increased when compared with those before treatment (P＜0.05)，but there was no significant difference being found in the comparison of BMI between the two groups (P＞0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞ 0.05). Conclusion：The therapy of Zhibai Dihuang Pills combined with Dipherelin has a significant curative effect on idiopathic central precocious puberty in girls， which can effectively regulate the levels of sex hormones in patients，delay the bone age maturation，and inhibit the growth of secondary sex character， with relatively high safety.