Abstract： Objective： To observe the administration rules of Chinese patent medicine for impotence based on data mining. Methods： The Chinese patent medicine used for impotence in Drug Standard of Ministry of Public Health of the People's Republic of China： Chinese Traditional Compound Medicine， Chinese Pharmacopoeia， Pharmacopoeia of People's Republic of China： Clinical Medication Notice， National Standard Compilation of Chinese Patent Medicine，National Drug Standard：Standard of New Drug Becoming Official were screened and sorted. The usage frequency，effects，nature，flavors and meridian entries of Chinese medicines included into Chinese patent medicine were analyzed，and the administration rules of Chinese patent medicine for impotence were summarized by complex network analysis， factor analysis and association rule analysis. Results：A total of 86 prescriptions were included，with 176 Chinese medicinals involved. The mostly used Chinese medicines are Lycii Fructus，Rehmanniae Radix Praeparata， Cuscutae Semen，Epimedh Folium，Cervi Cornu Pantotrichum，Angelicae Sinensis Radix and Cistanches Herba. Among them ， deficiency- supplementing medicinals ， astringent medicinals and dampnessdraining diurectic medicinals take the majority； the main meridian entries of Chinese medicinals are the kidney meridian，the liver meridian，and the spleen meridian；Chinese medicinals with warm and balanced nature account for the most；the flavor is mostly acrid and sweet. In line with the association rule analysis， the core combination of medicinals is Rehmanniae Radix Praeparata- Dioscoreae Rhizoma- Poria- Lycii Fructus. According to the complex network analysis，a total of six model combinations，including Angelicae Sinensis Radix- Astragali Radix- Glycyrrhizae Radix et Rhizoma- Atractylodis Macrocephalae Rhizoma- Paeoniae Radix Alba- Cynomorii Herba， Cervi Cornu Pantotrichum- Ginseng Radix et Rhizoma- Polygalae Radix-Ziziphi Spinosae Semem and Lycii Fructus-Schisandrae Chinensis Fructus-Rubi Fructus-Dioscoreae Rhizoma- Poria- Cinnamomi Cortex- Psoraleae Fructus. The cluster analysis suggested four combinations of Chinese medicinals ， including Rehmanniae Radix Praeparata- Angelicae Sinensis Radix- Morindae Officinalis Radix- Cistanches Herba- Cortex Eucommiae， Poria- Dioscoreae Rhizoma- Psoraleae Fructus- Schisandrae Chinenisis Fructus- Lycii Fructus， Astragali Radix- Glycyrrhizae Radix et Rhizoma and Cervi Cornu Pantotrichum- et Rhizoma Ginseng Radix. The combination of Chinese medicnals with the highest contribution rate in the factor analysis is Morindae Officinalis Radix- Eucommiae Cortex- Poria- Cistanches Herba. Conclusion：The core Chinese medicinals in the treatment of impotence by Chinese patent medicine are Lycii Fructus， Rehmanniae Radix Praeparata， Cuscutae Semen， Epimedh Folium， Cervi Cornu Pantotrichum，Angelicae Sinensis Radix and Cistanches Herba. The main treatment principle is to tonify the kidney and secure essence， and enrich and nourish the liver and spleen， combined with promoting urination， clearing heat and warming the middle energizer. In clinical， modified prescriptions， such as Wubi Shanyan Pills，Meiwei Dihuang Pills and Five-Seed Progeny Pills can be used for treatment based on syndrome differentiation.