Abstract： Objective： To observe the clinical effect of nasal packing with gauze strips with Bi'ning Prescription in Chinese medicine for children with allergic rhinitis and its effect on immune function. Methods：A total of 160 cases of children with allergic rhinitis were divided into the observation group and the control group according to the random number table method，with 80 cases in each group. The control group was treated with Mometasone Furoate Nasal Spray， and the observation group was treated with nasal packing with gauze strips with Bi'ning Prescription. Both groups were treated for 28 days. Scores of Visual Analogue Scale (VAS) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)， levels of inflammatory cytokines and eosinophils (EOS) count in nasal secretions，and levels of CD4+，CD8+，natural killer cells (NK cells) and CD4+/CD8+ ratio in peripheral blood in fasting condition were compared between the two groups before and after treatment； clinical effects in the two groups were compared according to Symptom Score Reduction Index (SSRI). Results： Before treatment， there was no significant difference being found in the comparison of VAS scores of nasal symptoms between the two groups (P＞0.05). After treatment， VAS scores of nasal symptoms in the two groups were decreased when compared with those before treatment (P＜0.05)， and the scores in the observation group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of interleukin- 4 (IL- 4)， interleukin- 10 (IL- 10)， transforming growth factor- β1 (TGF- β1)， and interleukin- 13 (IL- 13) in nasal secretions between the two groups (P＞0.05). After treatment， the levels of IL- 4 and IL- 13 in nasal secretions in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of IL- 10 and TGF- β1 were increased when compared with those before treatment (P＜0.05)；the levels of IL-4 and IL-13 in nasal secretions in the observation group were lower than those in the control group (P＜0.05)，and the levels of IL- 10 and TGF-β1 were higher than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of CD4+，CD8+，CD4+/CD8+，and NK cells in peripheral blood between the two groups (P＞0.05). After treatment，the levels of CD8+ in peripheral blood in the two groups were significantly decreased when compared with those before treatment (P＜0.05)，and the levels of CD4 + ， CD4 +/CD8 + ， and NK cells were significantly increased when compared with those before treatment (P＜0.05)；the level of CD8+ in the observation group was lower than that in the control group (P＜ 0.05)，and the levels of CD4+，CD4+/CD8+，and NK cells were higher than those in the control group (P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of EOS count in nasal secretions and immunoglobulin E (IgE) levels in serum between the two groups (P＞0.05). After treatment，EOS count in nasal secretions and IgE levels in serum in the two groups were decreased when compared with those before treatment (P＜0.05)；EOS count in nasal secretions and IgE levels in serum in the observation group were lower than those in the control group (P＜0.05). The total effective rate of clinical effect was 97.50% in the observation group，higher than that of 86.25% in the control group (P＜ 0.05). The incidence of adverse reactions and the recurrence rates within three months in the observation group were lower than those in the control group (P＜0.05). Conclusion：Nasal packing with gauze strips with Bi'ning Prescription in Chinese medicine has a definite curative effect in treating allergic rhinitis，and can reduce the levels of inflammatory factors in children，inhibit the activation of eosinophils and improve the immune function of children.