Abstract ： Objective ： To observe the clinical effect of V-shaped aupoint catgut embedding therapy with microneedle combined with ketogenic diet for simple obesity. Methods：A total of 80 cases of patients with simple obesity were divided into the control group and the observation group according to the random number table method， with 40 cases in each group. The control group was treated with ketogenic diet， and the observation group was treated with V-shaped acupuncture point burial with microneedle combined with ketogenic diet. Body mass，body mass index (BMI)，body fat mass (BFM)，visceral fat area (VFA)， skeletal muscle mass (SMM)，total body water (TBW) and inorganic salt mass before and after treatment were compared between the two groups；the clinical effects and the incidence of adverse reactions in the two groups were evaluated. Results：During treatment，3 cases were lost，2 cases were removed and 35 cases were completed in the control group；3 cases were lost，3 cases were removed and 34 cases were completed in the observation group. After treatment，the total effective rate in the observation group was higher than that in the control group (P＜0.05). After treatment，the body mass，BMI，BFM and VFA in both groups were significantly decreased compared with before treatment (P＜0.05)， and the above indexes in observation group were lower than those in control group (P＜0.05). After treatment，the TBW and SMM in the control group were obviously reduced when compared with those before treatment (P＜ 0.05)，and the TBW and SMM in the observation group were significantly higher than those in the control group (P＜0.05). Before and after treatment， there was no significant difference being found in the comparison of quality of inorganic salts between the two groups，as well as in the comparisons of TBW and SMM in the observation group (P＞0.05). No serious adverse reactions were observed in the two groups. Conclusion：V-shaped aupoint catgut embedding therapy with microneedle combined with ketogenic diet for simple obesity has a significant curative effect， which can reduce body mass and visceral fat and maintain muscle mass and TBW without serious adverse reactions.