Abstract：Objective：To observe the effect of Xingbei Zhike Granules combined with western medicine on the immune function and the lung function of children with community-acquired pneumonia. Methods： A total of 120 children with community- acquired pneumonia were selected as the research subjects and divided into the study group and the control group according to the random number table method， with 60 cases in each group. The control group was treated with routine western medicine，and the study group was additionally given Xingbei Zhike Granules based on the treatment of the control group. The two groups were treated for consecutive 7 days. Before and after treatment， the levels of granulocyte- macrophage colony-stimulating factor (GM-CSF)，interleukin-3 (IL-3)，interleukin-6 (IL-6)，tumor necrosis factor-α (TNF-α)， 25- hydroxyvitamin D [25(OH)D]，immunoglobulin- M (IgM)，immunoglobulin- A (IgA)，vitamin D， maximal expiratory pressure (PEmax)， maximal inspiratory pressure (PImax)， peak expiratory flow (PEF)，and maximum mid-expiratory flow (MMF) in the two groups were compared，as well as the clinical effect was evaluated. Results：The total effective rate was 96.67% in the study group，higher than that of 83.3% in the control group (P＜0.05). After treatment，the levels of GM-CSF，IL-6，TNF-α，and IL-3 in both groups were decreased when compared with those before treatment ， and the levels of IgM ， IgA ， 25(OH)D and vitamin D were increased (P＜0.05)；the levels of GM-CSF，IL-6，TNF-α，and IL-3 in the study group were lower than those in the control group，and the levels of IgM，IgA，25(OH)D and vitamin D were higher than those in the control group (P＜0.05). After treatment， the levels of PImax， PEmax，MMF and PEF in the two groups were increased when compared with those before treatment (P＜ 0.05)，and the above four levels in the study group were higher than those in the control group (P＜0.05). Conclusion：Xingbei Zhike Granules combined with routine western medicine for children with communityacquired pneumonia can inhibit the inflammatory responses， improve the immune function and the lung function of children，and increase the clinical effect.