Abstract：Objective：To observe the clinical effect of the therapy of Qili Qiangxin Capsules combined with Xinyue Capsules on patients with chronic heart failure after percutaneous coronary intervention (PCI) for coronary heart disease. Methods：A total of 80 patients with chronic heart failure after PCI for coronary heart disease were divided into the control group and the treatment group by random number table method，with 40 cases in each group. The control group was treated with conventional western medicine， and the treatment group was additionally treated with the therapy of Qili Qiangxin Capsules combined with Xinyue Capsules based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores，the distance of 6-minute walking test (6MWT)，the N-terminal pro-B-type natriuretic peptide (NT- proBNP) levels and echocardiographic parameters were compared between the two groups before and after treatment. The effects of the heart function and the occurrence of adverse reactions were evaluated between the two groups. Results：After treatment，the curative effect on the heart function in the treatment group was better than that in the control group (P＜0.05). After treatment， the TCM syndrome scores，the NT-proBNP levels，the left ventricular end-diastolic diameters (LVEDD) and the left ventricular end-systolic diameters (LVESD) were decreased in the two groups when compared with those before treatment (P＜0.05)； the left ventricular ejection fraction (LVEF) and the distance of 6MWT were increased (P＜0.05)，the TCM syndrome scores，NT-proBNP level，LVEDD and LVESD in the treatment group were less than those in the control group (P＜0.05)，and the LVEF and the distance of 6MWT were more than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The therapy of Qili Qiangxin Capsules combined with Xinyue Capsules has a definite effect on the treatment of chronic heart failure after PCI for coronary heart disease，which can effectively improve the heart function，activity tolerance and safety.