Abstract：Objective：To observe the clinical effect of Guanxinning Tablets combined with Trimetazidine for unstable angina pectoris of qi deficiency and blood stasis type. Methods：A total of 102 cases of patients with unstable angina pectoris of qi deficiency and blood stasis type were divided into the observation group and the control group according to the random number table method， with 51 cases in each group. The control group was treated with the oral administration with Trimetazidine based on routine treatment，and the observation group was additionally treated with Guanxinning Tablets based on the treatment of the control group. Traditional Chinese medicine (TCM) symptom scores， blood lipid indexes [total cholesterol (TC)， triglyceride (TG)， low- density lipoprotein cholesterol (LDL- C)， and high- density lipoprotein cholesterol (HDL- C)]，inflammatory factors [high- sensitivity C- reactive protein (hs- CRP)，interleukin- 6 (IL- 6)， tumor necrosis factor- α (TNF- α)， and human monocyte chemoattractant protein- 1 (MCP- 1)]， scores of Seattle Angina Rating Scale (SAQ) and Global Registry of Acute Coronary Event (GRACE)，and the frequency and duration of angina pectoris attacks were compared between the two groups before and after treatment. Clinical effects and the incidence of adverse reactions were evaluated in the two groups. Results：The total effective rate was 94.12% in the observation group，higher than that of 76.47% in the control group (P＜0.05). After treatment， the frequency and duration of angina pectoris attacks， TCM symptom scores，and GRACE scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and SAQ scores were increased (P＜0.05)； the frequency and duration of angina pectoris attacks，TCM symptom scores，and GRACE scores in the observation group were less than those in the control group (P＜0.05)，and the SAQ score was higher than that in the control group (P＜0.05). After treatment，TC，TG，LDL-C，hs-CRP，IL-6，TNF-α，and MCP-1 in the two groups were decreased when compared with those before treatment (P＜0.05)， and HDL- C was increased (P＜0.05)； the TC， TG，LDL-C，hs-CRP，IL-6，TNF-α，and MCP-1 in the observation group were lower than those in the control group (P＜0.05)，and the HDL-C was higher than that in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions (P＞0.05). Conclusion： Guanxinning Tablets combined with Trimetazidine has a definite curative effect in treating unstable angina pectoris of qi deficiency and blood stasis type，and can effectively regulate blood lipid levels of patients，and reduce inflammatory responses and risk degree，with high safety.