Abstract： Objective： To observe the effect of the therapy of Buyang Huanwu Decoction combined with Dagliazine on blood glucose control and urinary microalbumin levels in patients with early diabetic kidney disease (DKD). Methods： A total of 78 patients with early DKD were randomly divided into the observation group and the control group according to random number table method，with 39 cases in each group. The control group was treated with Dagliazine，and the observation group was additionally treated with Buyang Huanwu Decoction based on the treatment of the control group. The changes in the levels of fasting blood glucose (FBG)， postmortem 2h blood glucose (P2hBG)， glycosylated hemoglobin (HbA1c)， serum creatinine (SCr)， cystatin C (Cys C) and urinary albumin excretion rates (UAER) were compared between the two groups before and after treatment. Results：Before treatment，there was no significant difference in the levels of FBG， P2hBG and HbA1c between the two groups (P＞0.05). After treatment， the levels of FBG，P2hBG and HbA1c in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of FBG，P2hBG and HbA1c in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference in the levels of serum SCr，Cys C and UAER between the two groups (P＞0.05). After treatment，the levels of serum Cys C and UAER in the two groups were decreased when compared with those before treatment (P＜0.05)， and the serum Cys C and UAER levels in the observation group were lower than those in the control group (P＜0.05). Conclusion：The therapy of Buyang Huanwu Decoction combined with Dagliegin can effectively control the blood glucose levels of patients with early DKD，and can reduce the urinary microalbumin and protect the kidney function.