宋代官修方书中治疗虚劳方剂的用药规律挖掘研究
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R255.5

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中国中医科学院科技创新工程重点项目(C12021A00802);国家自然科学基金面上项目(81774282)


Research on the Medication Rules of Prescriptions for Consumptive Disease in the Official Prescription Books of the Song Dynasty
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    摘要:

    目的:通过整理宋代三部官修方书中主治虚劳的处方及虚劳疾病的症状表现,借助中医传承计算 平台V3.0 探究宋代医家治疗虚劳的用药、组方规律,并由此管窥宋代医家治疗虚劳的学术思想。方法:依 据《太平惠民和剂局方》《太平圣惠方》及《圣济总录》三部宋代官修方书中所载治疗虚劳的文献条目,提取 其中处方信息和主治症状等信息,利用Excel 2016 将处方信息规范化整理成数据库,基于中医传承计算平台 V3.0 对处方进行分析。结果:通过纳排标准筛选整理出97 首方剂,201 味中药;分析用药规律可知所用中药 的四气以温、寒、平为主;五味以甘、苦、辛为主;归经以脾、肺、肾三经为主;药物功效以补虚类、温里 类、化痰止咳平喘类为主;在药物使用频次上,最高频使用的5 味药物是肉桂、茯苓、人参、炙甘草、白术。 通过关联规则分析得出,使用频次最高的对药为人参-炙甘草;使用频次最高的角药为茯苓-人参-炙甘草。通 过K 均值聚类算法可将处方分为3 个聚类,并得出核心处方药物。结论:宋代医家治疗虚劳的处方具有鲜明 的用药规律,治疗上以“温肾助阳、健脾益气、理气化痰、滋阴清热”为原则,用药上注重脾肾同调、寒温相 配、气机升降、攻补兼施。

    Abstract:

    Abstract: Objective: By researching the prescriptions for consumptive disease in three official prescription books revised in the Song Dynasty, and with the help of the Traditional Chinese Medicine Inheritance Computing System V3.0 to explore the medication rules, prescription rules, and academic thoughts of the Song Dynasty physicians in treating consumptive disease. Methods: According to the literature entries for the treatment of consumptive disease contained in the three official prescriptions of the Song Dynasty, Taiping Huimin Heji Jufang (Beneficial Formulas from the Taiping Imperial Pharmacy), Taiping Shenghui Fang(Formulas from Benevolent Sages Complied During the Taipin Era) and Shengji Zonglu (Comprehensive Recording of Divine Assistance), the information on the prescription and the main symptoms were extracted. Using Excel 2016 to standardize the prescription information into a database, and analyze the prescription based on the TCMICS V3.0. Result: A total of 97 prescriptions and 201 Chinese herbal medicines were screened and sorted out according to the standard of inclusion and expulsion. The analysis of the medication rules showed that the four qi of Chinese herbal medicine used were mainly warm,cold and mild;the five flavors were mainly sweet,bitter and pungent. The channel entry of main three are the spleen channel,lung channel,kidney channel;the efficacy of the drugs are mainly supplementing, warming the interior, and dissipating phlegm, relieving cough and asthma; in terms of the frequency of drug use, the 5 most frequently used drugs are Cinnamomi Cortex, Poria, Ginseng Radix et Rhizoma, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle and Atractylodis Macrocephalae Rhizoma. Through the analysis of association rules, it was concluded that the most frequently used pair drug was Ginseng Radix et Rhizoma- Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle;the most frequently used triple drug was Poria- Ginseng Radix et Rhizoma- Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle. The prescriptions can be divided into 3 clusters by the K- means clustering algorithm, and the core prescription drugs can be obtained. Conclusion: The prescriptions of physicians in Song Dynasty for consumptive disease had distinct medication rules. Medication revolved around the principles of warming kidney and activating yang, invigorating the spleen and benefiting qi, regulating qi-flowing for eliminating phlegm, nourishing yin and clearing heat.

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周雪丹,苏铭琬,姚子昂.宋代官修方书中治疗虚劳方剂的用药规律挖掘研究[J].新中医,2023,55(5):42-48

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  • 在线发布日期: 2023-03-15
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