Abstract： Objective： To observe the curative effect of Lianzhu Xiaoke Prescription combined with Metformin on obesity type 2 diabetes mellitus (T2DM) with dampness blended with heat and blood stasis syndrome and its effect on glucose and lipid metabolism and inflammatory factors. Methods： A total of 66 patients with obesity T2DM with dampness blended with heat and blood stasis syndrome were selected and divided into the control group and the observation group according to the random number table method，with 33 cases in each group. The control group was treated with Metformin，and the observation group was additionally given Lianzhu Xiaoke Prescription based on the treatment of the control group. The clinical effects and incidence of adverse reactions in the two groups were compared. Before and after treatment， the changes of traditional Chinese medicine (TCM) syndrome scores， levels of indexes of glucose and lipid metabolism， including fasting blood glucose (FBG)， 2- hour postprandial blood glucose (P2hBG)，serum total cholesterol (TC) and triglyceride (TG)，and levels of inflammatory factors，including tumor necrosis factor-α (TNF-α)，interleukin-6 (IL-6) and C-reactive protein (CRP)，in both groups were compared. Results：The total clinical effective rate was 93.94% in the observation group，higher than that of 75.76% in the control group， the difference being significant (P＜0.05). After treatment， the TCM syndrome scores of thirst without desire to drink， heavy body and fatigue， poor appetite， obesity， numbness and stabbing pain of limbs， sticky stool， and short voidiongs of reddish urine in both groups were decreased when compared with those before treatment (P＜0.05)， and the above 7 scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of FBG，P2hBG，TC and TG in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above four levels in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of TNF- α， IL- 6 and CRP in both groups were decreased when compared with those before treatment (P＜0.05)， the above three levels in the observation group were lower than those in the control group (P＜0.05). Conclusion：With good safety，Lianzhu Xiaoke Prescription combined with Metformin has a sound curative effect on obesity T2DM with dampness blended with heat and blood stasis syndrome，which can effectively improve the glucose and lipid metabolism and decrease the levels of inflammatory factors，and the clinical effect is better than that of single Metformin.