Abstract： Objective： To observe the clinical effect of Qingfei Huatan Decoction combined with western medicine for senile patients with ventilator- associated pneumonia. Methods：A total of 60 cases of senile patients with ventilator-associated pneumonia were selected and randomly divided into the control group and the treatment group，with 30 cases in each group. The control group was given routine treatment for resisting infection， expelling phlegm and relieving muscular spasm and asthma， and the treatment group was additionally given oral administration of Qingfei Huatan Decoction based on the treatment of the control group. After 2-week treatment，the scores of Clinical Pulmonary Infection Score (CPIS) and Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE- Ⅱ) and the total clinical effect were compared between the two groups. Results：The total effective rate was 96.67% in the treatment group and 73.33% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of CPIS scores between the two groups (P＞0.05). After treatment， the CPIS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the CPIS score in the treatment group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of APACHE Ⅱ scores between the two groups (P＞0.05). After treatment， the APACHE Ⅱ scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the APACHEⅡ score in the treatment group was lower than that in the control group (P＜0.05). Conclusion：Qingfei Huatan Decoction combined with routine treatment in western medicine for senile patients with ventilator- associated pneumonia can improve clinical effect，effectively relieve pulmonary infection and improve health condition.