Abstract：Objective：To observe the clinical effect of ozone therapy combined with western medicine for systemic lupus erythematosus (SLE). Methods：A total of 50 cases of SLE patients were selected and divided into the trial group and the control group according to the random number table method ， with 20 and 30 cases in each group respectively；two cases dropped out in the trial group，and 4 cases in the control group. The control group was treated with western medicine，and the trial group was treated with ozone therapy combined with western medicine. Both groups were treated for 4 weeks，and the follow-up was carried out at the day of the end of treatment，and 2 months after treatment. The changes in Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores， gastrointestinal symptom grading scores， values of complement C3 and complement C4，and Health Status Questionnaire (SF-36) scores before and after treatment were compared between the two groups. The incidence of adverse reactions during treatment was observed between the two groups. Results： After 4- week treatment， SLEDAI scores in the two groups were decreased when compared with those before treatment (P＜0.05)； there was no significant difference being found in the comparison of SLEDAI scores between the two groups (P＞0.05). After 4- week treatment and during the 2- month follow- up， SF- 36 scores in the two groups were increased when compared with those before treatment (P＜0.05)，and the SF-36 scores in the trial group were higher than those in the control group in the same period (P＜0.05). After 4-week treatment and 2-month follow-up，the gastrointestinal symptom grading scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the gastrointestinal symptom grading scores in the trial group were lower than those in the control group in the same period，there being no significance in the difference (P＞0.05). After 4- week treatment， the values of complement C3 and complement C4 in the two groups were increased when compared with those before treatment，there being no significance in the difference (P＞0.05)；no significant difference being found in the comparison of the values of complement C3 and complement C4 between the two groups (P＞0.05). There was no adverse reaction during the trial in the two groups. Conclusion：Ozone therapy combined with western medicine has a good effect in treating SLE， and can promote the oxygen supply in the body， enhance the body immunity， and improve the quality of life of patients.