Abstract： Objective： To observe the clinical effect of acupuncture combined with Xuefu Zhuyu Decoction for chronic pelvic inflammatory disease (CPID) with stasis-toxin internal accumulation syndrome. Methods： A total of 122 cases of patients with CPID were divided into the control group and the observation group according to the ransom number table method， with 61 cases in each group. The control group was treated with Tinidazole， and the observation group was additionally treated with acupuncture combined with Xuefu Zhuyu Decoction based on the treatment of the control group. Before and after treatment， Visual Analogue Scale (VAS) scores， Self- rating Anxiety Scale (SAS) scores， traditional Chinese medicine (TCM) syndrome scores， inflammatory factors[C- reactive protein (CRP)， interleukin- 6 (IL- 6)，interleukin- 8 (IL- 8)，tumor necrosis factor- α (TNF- α)]，oxidative stress indexes [glutathione peroxidase (GSH- Px)， superoxide dismutase (SOD) and malondialdehyde (MDA)]， and hemorheology indexes were compared between the two groups；the clinical effects and the incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 75.41% in the control group and 91.80% in the observation group，the difference being significant (P＜0.05). After treatment， VAS scores， SAS scores and TCM syndrome scores in the two groups were significantly decreased when compared with those before treatment (P＜0.05)， and the reduction in the observation group was greater than that in the control group (P＜0.05). After treatment，the levels of CRP，IL-6，IL-8， TNF- α， plasma viscosity， whole blood high shear viscosity， hematocrit， and whole blood low shear viscosity in the two groups were significantly decreased when compared with those before treatment (P＜ 0.05)，and the decrease in the observation group was greater than that in the control group (P ＜ 0.05). After treatment ， the levels of GSH- Px and SOD in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of MDA were decreased (P＜0.05)；the improvement of the above indexes in the observation group was better than that in the control group (P＜0.05). The incidence of adverse reactions was 4.92% in the observation group， lower than that of 18.03% in the control group (P＜0.05). Conclusion：The therapy of acupuncture combined with Xuefu Zhuyu Decoction for CPID with stasis-toxin internal accumulation syndrome can effectively enhance the antioxidant capacity of patients，reduce inflammatory responses and improve blood circulation，with high safety.