Abstract：Objective：To observe the curative effect of Yihuang Decoction combined with recombinant interferon for cervical high- risk human papilloma virus (HR- HPV) infection and its effect on viral load. Methods：A total of 100 cases of patients with cervical HR-HPV infection were retrospectively selected and divided into the study group and the control group according to different treatment methods，with 50 cases in each group respectively. The control group was treated with recombinant interferon，and the study group was additionally given the oral administration of Yihuang Decoction based on the treatment of the control group. Both groups were treated for 2 menstrual cycles. The clinical effects in the two groups were evaluated. The traditional Chinese medicine (TCM) syndrome scores，the negative conversion of HPV，the viral load of HR- HPV and the incidence of adverse reactions before and after treatment in the two groups were compared. Results： The total effective rate was 92.00% in the study group， higher than that of 76.00% in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of TCM syndromes and the total scores between the two groups (P＞0.05). After treatment， the scores of TCM syndromes and the total scores in the two groups were lower than those before treatment (P＜0.05)，and the scores of TCM syndromes and the total score in the study group were lower than those in the control group (P＜0.05). The negative conversion rates of HPV in 3 months， 6 months and one year after treatment in the study group were higher than those in the control group (P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of viral load of HR-HPV between the two groups (P＞0.05). After treatment，the viral load of HR-HPV in the two groups was decreased when compared with that before treatment (P＜0.05)，and the viral load of HR-HPV in the study group was lower than that in the control group (P＜0.05). The incidence of adverse reactions was 4.00% in the study group，lower than that of 20.00% in the control group (P＜0.05). Conclusion：Yihuang Decoction combined with recombinant interferon has a significant curative effect in the treatment of cervical HR-HPV infection，which can improve the clinical symptoms of patients，decrease the viral load，promote the negative conversion of HPV，and reduce the incidence of adverse reactions.