Abstract： Objective： To observe the clinical effect of modified Xiaochuan Decoction combined with western medicine for children with acute exacerbation of bronchial asthma. Methods：A total of 164 cases of children with acute exacerbation of bronchial asthma were divided into the observation group and the control group according to the random number table method， with 82 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with modified Xiaochuan Decoction based on the treatment of the control group. Before and after treatment，the levels of peak expiratory flow (PEF)， forced expiratory volume in one second (FEV1)， and forced vital capacity (FVC) and the traditional Chinese medicine (TCM) syndrome scores were compared between the two groups. The clinical effects and the incidence of adverse reactions were compared between the two groups. Results：After treatment，the total effective rate in the observation group was higher than that in the control group (P＜0.05). After treatment， the levels of PEF， FEV1 and FVC in the two groups were significantly increased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores were decreased (P＜0.05)； the indexes of lung function and the improvement of TCM syndrome scores in the observation group were better than those in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：Modified Xiaochuan Decoction combined with western medicine for children with acute exacerbation of bronchial asthma can effectively improve lung function and TCM symptoms， with a significant clinical effect and high safety.