Abstract： Objective： To observe the clinical effect of the therapy of modified Liujunzi Decoction combined with proton pump inhibitor on peptic ulcer disease in the active stage. Methods ： A total of 94 patients with peptic ulcer disease in the active stage were selected and divided into the control group and the observation group according to the random number table method，with 47 cases in each group. The control group was treated with proton pump inhibitor，and the observation group was additionally treated with modified Liujunzi Decoction on the basis of the treatment of the control group. The clinical effects and recurrence rate one year after treatment were compared between the two groups. The changes in the traditional Chinese medicine(TCM) syndrome scores， scores of Visual Analogue Scale (VAS)， clinical symptoms， gastric mucosal histological scores and inflammatory factors， including C- reactive protein (CRP)， tumor necrosis factor- α (TNF- α) and interleukin- 6 (IL- 6)， before and after treatment were compared between the two groups. The incidence of adverse reactions in the two groups was also observed. Results：The total effective rate was 93.62% in the observation group and 78.72% in the control group， the difference being significant (P＜0.05). After treatment， the TCM syndrome scores and VAS scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the two scores in the observation group were lower than those in the control group (P＜0.05). The disappearance time of stomachache and ulcer healing time in the observation group were shorter than those in the control group，differences being significant (P＜0.05). After treatment，the levels of inflammatory cell infiltration， inflammatory activity， mucosal thickness， glandular density as well as the histological scores of gastric mucosae of glandular morphology in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above gastric mucosal histological scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of CRP， TNF- α and IL- 6 in both groups were decreased when compared with those before treatment (P＜0.05)；the above 3 indexes in the observation group were lower than those in the control group (P＜0.05). The recurrence rate was 9.30% in the observation group and 34.29% in the control group， the difference being significant (P＜0.05). Conclusion：The therapy of modified Liujunzi Decoction combined with proton pump inhibitor has a sound clinical effect on peptic ulcer disease in the active stage，which can relieve the clinical symptoms，improve the gastric mucosal function，and reduce the inflammatory responses，with a low recurrence rate.