Abstract：Organ fibrosis can occur in the lungs，liver，kidneys，heart and other parenchymal organs， which will lead to the structure destruction and function loss of organs， seriously threatening health of patients. A large number of studies have found that traditional Chinese medicine(TCM) can regulate fibroblast growth factor (FGF)/fibroblast growth factor receptors (FGFRs) signaling pathway to reduce inflammatory cell infiltration and fibroblast differentiation at the site of tissue injury and inhibit the fibrosis of the lungs，liver，kidneys and myocardium. The authors systematically summarized the role of FGF/FGFRs signaling pathway in organ fibrosis and the research progress of the mechanism of the TCM treatment，so as to provide reference for TCM in treating organ fibrosis.