Abstract：This article aims to introduce Prof. ZHONG Guanghui's clinical experience in treating female urethral syndrome from the spirit. Urethral syndrome is characterized by recurrent frequent urination， urination urgency and dysuria，accompanied by obvious emotional anxiety，but no abnormalities are found in relevant examinations. Prof. ZHONG believes that restlessness and loss of nourishment of heart spirit are the root of emotional abnormalities， and the uncontrolled bladder qi transformation is the key to urinary tract symptoms. Therefore，when treating female urethral syndrome，the most important is to regulate the spirit and treat from the spirit. And he established the methods of resolving constraint and resting the heart to calm spirit，clearing heat and draining dampness to stabilize spirit，supplementing and boosting the heart and spleen to rest spirit，and warming and supplementing the spleen and kidney to nourish spirit，and he combined the methods with emotional guidance and other comprehensive nursing，which together calms heart spirit to facilitate bladder qi transformation.