Abstract：Objective：To observe the clinical effect of the therapy of Kouyanqing Granules on chronic periodontitis and its effect on levels of inflammatory factors in gingival crevicular fluid. Methods：A total of 62 patients with chronic periodontitis were selected and divided into the treatment group and the control group according to the random number table method， with 31 cases in each group. Both groups were received the routine intervention measures of western medicine. The control group was treated with Roxithromycin Capsules and Tinidazde Tablets， and the treatment group was additionally treated with Kouyanqing Granules based on the treatment of the control group. After 4 weeks of treatment，the clinical effects，periodontal indexes and levels of tumor necrosis factor(TNF)- α and interleukin(IL)- 1β in gingival crevicular fluid were compared between the two groups. Results：The total effective rate was 93.55% in the treatment group， significantly higher than that of 70.97% in the control group， the difference being statistically significant(P＜0.05). Before treatment，no significant difference was found in the comparisons of plaque index， gingival index， probe depth， and sulcus bleeding index between the two groups(P＞ 0.05). After treatment，the above indexes in both groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above indexes in the treatment group were significantly lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of TNF- α and IL- 1β in gingival crevicular fluid between the two groups(P＞ 0.05). After treatment ， TNF- α and IL- 1 β levels in both groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above levels in the treatment group were lower than those in the control group(P＜0.05). Conclusion：Based on routine western medicine treatment，the therapy of Kouyanqing Granules can effectively inhibit the inflammatory responses in patients with chronic periodontitis，significantly improve the symptoms and signs of patients，and enhance the curative effect.