Abstract：Objective：To observe the clinical effect of the therapy of Xiao'er Zhupo Powder combined with conventional western medicine on infantile cough with syndrome of wind- heat invading the lung. Methods： A total of 82 cases with infantile cough with syndrome of wind- heat invading the lung were randomly divided into the control group and the treatment group，with 41 cases in each group. The control group was treated with Amoxicillin- Clavulanate Potassium Dry Suspension combined with Ambroxol Hydrochloride Oral Solution，and the treatment group was additionally treated with Xiao'er Zhupo Powder based on the treatment of the control group. The course of treatment in both groups was seven days. The disappearance time of symptoms and signs， syndrome scores of wind- heat invading the lung and the overall clinical effects were compared between the two groups. Results： The total effective rate was 97.56% in the treatment group， and 80.49% in the control group， there being no significant difference between the two groups(P＜0.05). The disappearance time of cough，expectoration，dry and wet rales and fever in the treatment group was respectively shorter than that in the control group，the difference being significant(P＜0.05). Before treatment， there was no significant difference in the scores of cough， expectoration，sore throat，fever and thirst of syndrome of wind-heat invading the lung between the two groups(P＞0.05)；after treatment，the scores of the above syndromes in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and each score in the treatment group was lower than that in the control group(P＜0.05). Conclusion： On the basis of conventional western medicine，the additional application of Xiao'er Zhupo Powder can significantly improve the symptoms and signs of patients with infantile cough with syndrome of wind- heat invading the lung， and improve the clinical effect.