Abstract：Objective：To observe the clinical effect of the therapy of Fufang Xianzhuli Ye combined with azithromycin on mycoplasma pneumonia(MPP) in children. Methods：A total of 96 children with MPP were selected and divided into the control group and the trial group according to the random number table method，with 48 cases in each group. Both groups were given basic symptomatic treatment. The control group was additionally treated with Azithromycin，and the trial group was additionally treated with Fufang Xianzhuli Ye based on the treatment of the control group. Both groups were treated for two weeks. The total clinical effective rates，incidence of adverse reactions，disappearance time of symptoms and the changes of levels of related indexes of lung function，including respiratory rate(RR)，forced expiratory volume in one second(FEV1) and peak expiratory flow(PEF)，serum inflammatory factors indexes，including interleukin- 6 (IL- 6)， interleukin- 10(IL- 10) and C- reactive protein(CRP)， before and after treatment were compared between the two groups. Results：After treatment，the total effective rate was 95.83%% in the trial group and 83.33% in the control group，the difference being significant(P＜0.05). The disappearance time of fever subsidence，lung rales and cough in the trial group was significantly shorter than that in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of lung function indexes， including RR， FEV1 and PEF， between the two groups(P＞0.05)； after treatment， the levels of FEV1 and PEF in the two groups were increased when compared with those before treatment(P＜0.05)， and the levels of RR were decreased(P＜0.05)； the improvement in the above three levels in the trial group was better than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparisons of levels of IL- 6， IL-10 and CRP between the two groups(P＞0.05)；after treatment，the levels of serum IL-6，IL-10 and CRP in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above three levels in the trial group were lower than those in the control group(P＜0.05). During treatment，the incidence of adverse reactions was 4.17% in the trial group and 6.25% in the control group， there being no significance in the difference(P＞0.05). Conclusion： The therapy of Fufang Xianzhuli Ye combined with antibiotics for MPP in children can effectively relieve the clinical symptoms of children， reduce the inflammatory levels，and improve the lung function symptoms，with high total clinical effective rates and no obvious increase of adverse reactions.