银杏叶片联合西药治疗稳定型心绞痛临床研究
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R541.4

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Clinical Study on Yinxingye Tablets Combined with Western Medicine for Stable Angina Pectoris
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    摘要:

    目的:观察银杏叶片联合西药治疗稳定型心绞痛(SAP) 的临床疗效及对患者心功能、血液流变 学的影响。方法:采用随机数字表法将390 例SAP 患者分为对照组和观察组,每组195 例。对照组给予常规 西药治疗,观察组在对照组基础上加用银杏叶片治疗,2 组均治疗6 周。比较2 组临床疗效、心绞痛发作次数 和持续时间,以及治疗前后中医证候评分、心功能指标、血液流变学指标。结果:治疗后,2 组胸痛、心悸、 乏力评分均较治疗前降低,观察组上述评分均低于对照组,差异均有统计学意义(P<0.05)。2 组心绞痛发作 次数均较治疗前减少,观察组心绞痛发作次数少于对照组,差异均有统计学意义(P<0.05);2 组心绞痛持续 时间均较治疗前缩短,观察组心绞痛持续时间短于对照组,差异均有统计学意义(P<0.05);2 组左室收缩末 期内径(LVESD)、左室舒张末期内径(LVEDD) 均较治疗前缩小(P<0.05),左室射血分数(LVEF) 均较治 疗前升高(P<0.05);观察组LVESD、LVEDD 均小于对照组(P<0.05),LVEF 高于对照组(P<0.05);2 组 全血高切黏度、血浆黏度、红细胞沉降率、血细胞比容、纤维蛋白原水平均较治疗前降低,观察组上述指标评 分均低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率89.74%,高于对照组78.46% (P< 0.05)。结论:银杏叶片联合西药治疗SAP 临床疗效较好,可改善患者的临床症状、心功能和血液流变学。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Yinxingye Tablets combined with western medicine for stable angina pectoris(SAP) and its effect on heart function and hemorheology. Methods: A total of 390 cases of SAP patients were divided into the control group and the observation group according to the random number table method, with 195 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Yinxingye Tablets based on the treatment of the control group. Both groups were treated for six weeks. Traditional Chinese medicine syndrome scores,heart function indexes and hemorheology indexes before and after treatment as well as the clinical effects and the frequency and duration of angina attacks were compared between the two groups. Results:After treatment,the scores of chest pain,palpitations and lack of strength in two groups were decreased, the difference being statistically significant(P<0.05), and the above scores in the observation group were lower than those in the control group,the difference being statistically significant (P<0.05). After treatment, the frequency of angina attacks in the two groups were decreased and the duration of angina pectoris were shortened, the difference being statistically significant(P<0.05); the frequency of angina attacks in the observation group was less than that in the control group(P<0.05),and the duration of angina pectoris was shorter than that in the control group(P<0.05). After treatment,the left ventricular end systolic diameter(LVESD) and left ventricular end diastolic diameter(LVEDD) in the two groups were decreased(P<0.05), and the left ventricular ejection fraction(LVEF) was increased(P<0.05); LVESD and LVEDD in the observation group were lower when compared with those in the control group, and the LVEF was higher than that in the control group(P<0.05). After treatment,whole blood high shear viscosity, plasma viscosity, erythrocyte sedimentation rate, hematocrit and fibrinogen levels in both groups were decreased(P<0.05),and the levels of the above five hemorheology indexes in the observation group were lower than those in the control group,the difference being statistically significant(P<0.05). The effective rate was 89.74% in the observation group,higher than that of 78.46% in the control group(P< 0.05). Conclusion:The therapy of Yinxingye Tablets combined with western medicine for SAP has a good clinical effect,and can improve the clinical symptoms,heart function and hemorheology of patients.

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蔡子奇.银杏叶片联合西药治疗稳定型心绞痛临床研究[J].新中医,2023,55(2):61-64

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  • 在线发布日期: 2023-01-29
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