Abstract：Objective：To observe the clinical effect of modified Danggui Liuhuang Decoction combined with Irbesartan for type 2 diabetic nephropathy(DN) with qi- yin deficiency syndrome. Methods：A total of 126 cases of patients with type 2 DN(stage III) were screened and randomly divided into the control group and the treatment group， with 63 cases in each group. Both groups were treated with conventional treatments such as controlling blood lipids and blood glucose； the control group was additionally treated with oral administration with Irbesartan Tablets；the treatment group was additionally treated with modified Danggui Liuhuang Decoction based on the treatment of the control group. After 12 weeks of continuous treatment， the levels of kidney function indexes[24- hour urine protein， blood urea nitrogen(BUN)， and serum creatinine(SCr)]， the scores of qi- yin deficiency syndrome， and clinical effects were compared between the two groups. Results： The total effective rate was 88.89% in the treatment group， and 73.02% in the control group，the difference being significant when comparing between the two groups(P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of levels of 24- hour urine protein ， BUN， and SCr between the two groups(P＞0.05). After treatment， levels of 24-hour urine protein，BUN，and SCr in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the three kidney function indexes in the treatment group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of traditional Chinese medicine(TCM) syndrome scores of fatigue and lack of strength， palpitations and shortness of breath，dizziness，spontaneous sweating，and night sweat between the two groups(P＞0.05)；after treatment，the above TCM syndrome scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and each score in the treatment group was lower than that in the control group(P＜0.05). Conclusion： Modified Danggui Liuhuang Decoction combined with Irbesartan for type 2 DN with qi- yin deficiency syndrome can further improve kidney function，TCM syndromes，and clinical effects.