Abstract： Objective： To observe the clinical effect of modified Wendan Decoction combined with routine western medicine for coronary heart disease of turbid phlegm type. Methods：A total of 126 cases of patients with coronary heart disease of turbid phlegm type were selected as the study subjects， and randomly divided into the control group and the study group， with 63 cases in each group. The control group was treated with routine western medicine(Aspirin， Isosorbide Mononitrate and Simvastatin)， and the study group was additionally treated with modified Wendan Decoction based on the treatment of the control group. The changes in the levels of blood lipid including triglyceride(TG) and low-density lipoprotein cholesterol(LDL- C)， and the indexes of vascular endothelial function including nitric oxide(NO) and endothelin(ET) before and after treatment，as well as the curative effects were compared between the two groups. Results：The total effective rate was 96.8% in the study group and 84.1% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of LDL- C and TG in serum between the two groups(P＞0.05)；after treatment， the levels of LDL-C and TG in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above two indexes in the study group were lower than those in the control group(P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of levels of NO and ET in serum between the two groups(P＞0.05). After treatment，the NO levels in the two groups were increased when compared with those before treatment(P＜0.05)， and the ET levels were decreased(P＜ 0.05)；the improvement of the above two indexes in the study group was more significant than that in the control group(P＜0.05). During treatment，the total incidence of adverse reactions was 3.2% in the study group and 4.8% in the control group， there being no significance in the difference(P＞0.05). Conclusion： Modified Wendan Decoction combined with routine western medicine has a significant clinical effect in treating coronary heart disease of turbid phlegm type，which can obviously improve levels of blood lipid and vascular endothelial function in patients with good medication safety.