膈下逐瘀汤加减联合雌孕激素序贯疗法治疗人工流产术后月经过少临床研究
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Clinical Study on Modified Gexia Zhuyu Decoction Combined with Sequential Estrogen and Progestogen Therapy for Hypomenorrhea After Induced Abortion
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    摘要:

    目的:观察膈下逐瘀汤加减联合雌孕激素序贯疗法治疗人工流产术后月经过少的临床疗效。方 法:将82 例人工流产术后月经过少患者按随机数字表法分为对照组和观察组,每组41 例。对照组实施雌孕激 素序贯疗法治疗,观察组在对照组基础上给予膈下逐瘀汤加减治疗。21 d 为1 个疗程,2 组均治疗3 个疗程。 比较2 组临床疗效、不良反应发生率,以及治疗前后的月经情况、阴道超声检查指标。结果:治疗后,观察组 临床疗效总有效率92.68%,高于对照组75.61%(P<0.05)。2 组行经时间均较治疗前增加(P<0.05),月经 失血图评分法(PBAC) 评分均较治疗前升高(P<0.05);观察组行经时间长于对照组(P<0.05),PBAC 评分 高于对照组(P<0.05)。2 组子宫动脉搏动指数(PI)、子宫动脉阻力指数(RI) 均较治疗前降低(P<0.05), 子宫内膜厚度均较治疗前增加(P<0.05);观察组PI、RI 均低于对照组(P<0.05),子宫内膜厚度值大于对 照组(P<0.05)。观察组不良反应发生率12.20%,与对照组17.07%比较,差异无统计学意义(P>0.05)。结 论:膈下逐瘀汤加减联合雌孕激素序贯疗法治疗人工流产术后月经过少,可显著改善患者的月经及子宫血流情 况,促进子宫内膜修复,安全性好。

    Abstract:

    Abstract:Objective:To observe the clinical effect of modified Gexia Zhuyu Decoction combined with sequential estrogen and progestogen therapy for hypomenorrhea after induced abortion. Methods:A total of 82 cases of patients with hypomenorrhea after induced abortion were divided into the control group and the observation group according to the random number table method, with 41 cases in each group. The control group was treated with sequential estrogen and progestogen therapy, and the observation group was additionally treated with modified Gexia Zhuyu Decoction based on the treatment of the control group. Both groups were treated for three courses, with 21 days being one course. Menstruation and vaginal ultrasound indicators before and after treatment, as well as clinical effects and the incidence of adverse reactions were compared between the two groups. Results: The total effective rate was 92.68% in the observation group,higher than that of 75.61% in the control group(P<0.05). After treatment,menstrual periods in the two groups were lengthened when compared with those before treatment(P<0.05),and the scores of Pictorial Blood Loss Assessment(PBAC) were increased when compared with those before treatment(P<0.05);the menstrual period in the observation group was longer than that in the control group (P<0.05), and PBAC score was higher than that in the control group(P<0.05). After treatment, uterine artery pulsation index(PI) and uterine artery resistance index(RI) in the two groups were decreased when compared with those before treatment(P<0.05), endometrial thickness was larger when compared with that before treatment(P<0.05);PI and RI in the observation group were lower(P<0.05),and endometrial thickness was larger than those in the control group(P<0.05). The incidence of adverse reactions was 12.20% in the observation group and 17.07% in the control group, there being no significance in the difference(P>0.05). Conclusion:Modified Gexia Zhuyu Decoction combined with sequential estrogen and progestogen therapy for hypomenorrhea after induced abortion can significantly improve menstruation and uterine blood flow of patients,and promote endometrium regeneration with good safety.

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徐春丽,褚红杰.膈下逐瘀汤加减联合雌孕激素序贯疗法治疗人工流产术后月经过少临床研究[J].新中医,2023,55(2):18-22

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  • 在线发布日期: 2023-01-29
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