Abstract： Objective： To observe the clinical effect of Sini Powder combined with Diandao Mujin Powder for chronic non- atrophic gastritis(CNAG) caused by helicobacter pylori(Hp) infection with liverstomach qi stagnation syndrome. Methods： A total of 64 cases of patients with CNAG caused by Hp infection with liver- stomach qi stagnation syndrome were selected and randomly divided into the control group and the treatment group，with 32 cases in each group. The control group was treated with bismuth quadruple therapy， and the treatment group was additionally treated with Sini Powder combined with Diandao Mujin Powder based on the treatment of the control group. After two-week treatment，the scores of Gastrointestinal Symptom Rating Scale(GSRS) and liver- stomach qi stagnation syndrome， the Hp eradication rate and the clinical effects were compared between the two groups. Results： The total effective rate was 90.63% in the treatment group and 65.63% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of GSRS score between the two groups(P＞0.05). After treatment， GSRS scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the GSRS score in the treatment group was significantly lower than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the scores of liver- stomach qi stagnation syndrome，including stuffiness and fullness in stomach duct，distending pain in stomach duct，distention and fullness in ribs， and belching between the two groups(P＞0.05). After treatment， the scores of the above syndromes in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the scores in the treatment group were lower than those in the control group(P＜ 0.05). The Hp eradication rate was 84.38% in the treatment group and 56.25% in the control group，there being significant difference between the two groups(P＜0.05). Conclusion： Based on routine western medicine treatment，the additional therapy of Sini Powder combined with Diandao Mujin Powder for CNAG caused by Hp infection with liver- stomach qi stagnation syndrome can effectively improve the clinical symptoms of patients，the Hp eradication rate and the total clinical effect.