Abstract： Objective： To observe the clinical effect of the therapy of catgut embedment in point combined with Yunzhong Jianpi decoction on premature ovarian insufficiency. Methods：A total of 80 cases with premature ovarian insufficiency were selected and divided into the Chinese medicine group and the combination group according to the random number table method， with 40 cases in each group. The Chinese medicine group was treated with Yunzhong Jianpi Decoction， and the combination group was additionally given catgut embedment in point based on the treatment of the Chinese medicine group. Both groups were treated for 12 weeks. The traditional Chinese medicine(TCM) syndrome scores and Symptom Check List- 90(SCL- 90) scores at different time points were compared between the two groups， the serum hormone levels at different time points were detected，and the clinical effects in the two groups were evaluated. Results：The total effective rate was 87.5% in the combination group，higher than that of 70.0% in the Chinese medicine group， the difference being significance(P＜0.05). After four， eight and twelve weeks of treatment，the scores of main symptoms and secondary symptoms in the two groups were decreased when compared with those before treatment(P＜0.05)； and the above scores in the combination group were lower than those in the Chinese medicine group at the same period respectively(P＜ 0.05). After four， eight and twelve weeks of treatment， the SCL- 90 scores in the two groups were decreased when compared with those before treatment(P＜0.05)； and the SCL- 90 scores in the combination group were lower than those in the Chinese medicine group at the same period respectively(P＜ 0.05). After four， eight and twelve weeks of treatment， levels of luteinizing hormone(LH)， follicle stimulating hormone(FSH)，progesterone(P) and testosterone(T) in the two groups were decreased when compared with those before treatment，and the levels of estradiol(E2) and prolactin(PRL) were increased(P＜ 0.05)； the levels of LH， FSH and P in the combination group were lower than those in the Chinese medicine group at the same period respectively(P＜0.05)，and the E2 level in the combination group was higher(P＜0.05). Conclusion：The therapy of catgut embedment in point combined with Yunzhong Jianpi Decoction for premature ovarian insufficiency can significantly improve the clinical symptoms of patients and adjust the hormone levels，with a better clinical effect.