Abstract：Objective：To observe the clinical effect of acupuncture combined with Sanpian Decoction for migraine. Methods： A total of 108 cases of patients with migraine were selected as the research objects， and divided into the control group and the trial group according to the random number table method， with 54 cases in each group. With two cases in the control group and three cases in the experiment group dropped out，52 cases in the control group and 51 cases in the trial group were finally included. The control group was treated with Flunarizine Tablets， and the trial group was treated with acupuncture combined with Sanpian Decoction. Both groups were treated for four weeks. The clinical effects and the incidence of adverse reactions in the two groups were observed；the recurrence rates were compared between the two groups； the changes in seizure frequency and mean duration of headache， Visual Analogue Scale(VAS) of pain， traditional Chinese medicine(TCM) syndrome scores， levels of 5- hydroxytryptamine(5- HT)， endothelin- 1(ET- 1)， calcitonin gene- related peptide(CGRP)， dopamine(DA) and nitric oxide(NO) in serum before and after treatment were compared between the two groups. Results：After treatment，the seizure frequency and mean duration of headache，VAS scores and TCM syndrome scores in the two groups were decreased when compared with those before treatment(P＜ 0.05)， and the above four indexes in the trial group were lower than those in the control group(P＜0.05). The total effective rate of clinical effect was 84.31% in the trial group and 67.31% in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 3.92% in the trial group and 13.46% in the control group，the difference being significant(P＜0.05). The recurrence rate was 9.76% in the trial group and 45.71% in the control group，the difference being significant(P＜0.05). After treatment， the levels of 5- HT， CGRP and DA in the two groups were increased when compared with those before treatment，and the levels of ET- 1 and NO were decreased，differences being significant(P＜0.05). After treatment， the levels of 5- HT， CGRP and DA in the trial group were higher than those in the control group， and the levels of ET- 1 and NO were lower， differences being significant(P＜0.05). Conclusion： The therapy of acupuncture combined with Sanpian Decoction for migraine has a definite curative effect， which can improve the seizure frequency and duration of headache，reduce the degree of pain and enhance the long-term curative effect，with high safety.