Abstract： Objective： To observe the effect of acupuncture on neurological function and levels of intercellular adhesion molecule- 1(ICAM- 1) and insulin- like growth factor- 1(IGF- 1) in serum in patients with cerebral infarction in convalescence. Methods：A total of 94 cases of patients with cerebral infarction in convalescence were divided into the control group and the treatment group according to the random number table method，with 47 cases in each group. Both groups were given basic treatment；the control group was treated with routine western medicine，and the treatment group was additionally treated with acupuncture based on the treatment of the control group. The scores of National Institutes of Health Stroke Scale(NIHSS) and Barthel Index for activities of daily living(Barthel)， the levels of ICAM- 1 and IGF- 1 in serum before and after treatment，and the clinical effects and the adverse reactions after treatment in the two groups were observed. Results：The total clinical effective rate was 93.62% in the treatment group， higher than that of 70.21% in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of NIHSS and Barthel between the two groups(P＞0.05). After treatment，the NIHSS scores in the two groups were decreased(P＜0.05)，and Barthel scores were increased(P＜0.05)；the NIHSS score in the treatment group was lower，and Barthel score was higher than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of ICAM- 1 and IGF- 1 in serum between the two groups(P＞0.05). After treatment， the ICAM-1 levels in serum in the two groups were decreased(P＜0.05)，and IGF-1 levels in serum were increased(P＜0.05)；the ICAM-1 level in serum in the treatment group was lower，and the IGF-1 level in serum was higher than that in the control group(P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P＞0.05). Conclusion： The application of acupuncture has a significant clinical effect in treating cerebral infarction in convalescence， and is helpful to improve neurological function and self- care ability. It may be related to that acupuncture can effectively regulate the levels of ICAM-1 and IGF-1 in serum.