Abstract：Objective：To observe the clinical effect of Jianpi Qingre Jiedu Prescription combined with routine therapy for henoch-schionlein purpura nephritis(HSPN) of internal obstruction of damp-heat，blood stasis and toxin type in children. Methods：A total of 50 cases of HSPN of internal obstruction of damp-heat blood stasis and toxin type were selected and divided into the control group and the observation group according to the random number table method，with 25 cases in each group. The control group was given routine therapy and the observation group was additionally treated with Jianpi Qingre Jiedu Prescription based on the treatment of the control group. Both groups were treated for three months. The clinical effects and incidence of adverse reactions in both groups were observed，and the changes of traditional Chinese (TCM) medicine syndrome scores ， renal function indexes ， including 24- hour urinary protein content ， urine red blood cells ， kidney injury molecule(KIM-1)， and neutrophil gelatinase-associated lipocalin(NGAL) ， and the immune function indexes，including immunoglobulin A(lgA)，immunoglobulin G (lgG)，immunoglobulin M(lgM)，a proliferation inducing ligand(APRIL)，and B- cell activating factor of the TNF family(BAFF) were compared in both groups before and after treatment. Results： The total effective rate was 96.00% in the observation group，higher than that of 68.00% in the control group，the difference being significant(P＜0.05). After treatment， the TCM syndrome scores of edema， bloody urine， bitter taste and sticky mouth，dry mouth，distress and fullness in the chest，and fatigue and heaviness of the head and body in both groups were decreased when compared with those before treatment，and the above six scores in the observation group were lower than those in the control group(P＜0.05). After treatment， the indexes of 24- hour urinary protein content， urine red blood cells， KIM- 1， and NGAL in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above four indexes in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of IgA， IgG， IgM and APRIL in the two groups were decreased when compared with those before treatment，and the BAFF levels were increased，differences being significant(P＜0.05)；the levels of IgA， IgG，IgM and APRIL in the observation group were lower than those in the control group，and the BAFF level was higher，differences being significant(P＜0.05). The incidence of adverse reactions was 4.00% in the observation group， lower than that of 12% in the control group， there being no significance in the difference(P＞0.05). Conclusion：Jianpi Qingre Jiedu Prescription combined with routine therapy for HSPN of internal obstruction of dam- heat， blood stasis and toxin type in children can alleviate the clinical symptoms，improve the kidney function indexes and immunologic derangement，and enhance the clinical effect.